Light at Night and Breast Cancer Risk Among California Teachers
Light at Night and Breast Cancer Risk Among California Teachers
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DOI：
10.1097/ede.0000000000000137
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发表时间：
2014-09-01
期刊：
影响因子：
5.4
通讯作者：
Reynolds, Peggy
中科院分区：
文献类型：
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作者：
Hurley, Susan;Goldberg, Debbie;Reynolds, Peggy
背景：有令人信服的证据表明，夜间光照引起的昼夜节律紊乱促进了啮齿类动物的乳腺癌发生。夜间光线在人类乳腺癌病因学中所起的作用尚不清楚。我们评估了加州教师研究中心成员的室内和室外夜间灯光与乳腺癌风险之间的关系。方法：室内夜间灯光的估计基于有关睡眠习惯和夜间睡眠时使用灯光的问卷数据。对夜间室外光线的估计是从美国国防气象卫星计划获得的图像数据得出的，该计划分配给研究参与者的地理编码地址。对106,731名加州教师研究成员进行了分析，这些成员住在加州，以前没有乳腺癌病史，并提供了睡眠时吸烟的信息。1995年至2010年确诊的5,095例浸润性乳腺癌病例通过与加州癌症登记处的链接进行了确认。我们使用年龄分层的COX比例风险模型计算风险比(HR)，可信区间(CI)为95%，调整了乳腺癌危险因素、社区城市化和社会经济阶层。结果：生活在夜间户外光照估计值最高五分之一的地区的女性风险增加(HR=1.12[95%CI=1.00-1.26]；趋势检验，P=0.06)。尽管这种关联在绝经前女性中更为明显(HR=1.34[95%CI=1.07-1.69]；趋势检验，P=0.04)，但这种关联在绝经状态之间没有统计学差异(交互作用检验，P=0.34)。结论：生活在夜间环境光线高水平地区的妇女患乳腺癌的风险可能会增加。未来有必要对夜间室内和室外光线进行定量测量。
Background: There is convincing evidence that circadian disruption mediated by exposure to light at night promotes mammary carcinogenesis in rodents. The role that light at night plays in human breast cancer etiology remains unknown. We evaluated the relationship between estimates of indoor and outdoor light at night and the risk of breast cancer among members of the California Teachers Study.Methods: Indoor light-at-night estimates were based on questionnaire data regarding sleep habits and use of nighttime lighting while sleeping. Estimates of outdoor light at night were derived from imagery data obtained from the US Defense Meteorological Satellite Program assigned to geocoded addresses of study participants. Analyses were conducted among 106,731 California Teachers Study members who lived in California, had no prior history of breast cancer, and provided information on lighting while sleeping. Five thousand ninety-five cases of invasive breast cancer diagnosed 1995-2010 were identified via linkage to the California Cancer Registry. We used age-stratified Cox proportional hazard models to calculate hazard ratios (HRs) with 95% confidence intervals (CIs), adjusting for breast cancer risk factors and neighborhood urbanization and socioeconomic class.Results: An increased risk was found for women living in areas with the highest quintile of outdoor light-at-night exposure estimates (HR = 1.12 [95% CI = 1.00-1.26]; test for trend, P = 0.06). Although more pronounced among premenopausal women (HR = 1.34 [95% CI = 1.07-1.69]; test for trend, P = 0.04), the associations did not differ statistically by menopausal status (test for interaction, P = 0.34).Conclusions: Women living in areas with high levels of ambient light at night may be at an increased risk of breast cancer. Future studies that integrate quantitative measurements of indoor and outdoor light at night are warranted.