INDOOR RADON EXPOSURE AND ACTIVE AND PASSIVE SMOKING IN RELATION TO THE OCCURRENCE OF LUNG-CANCER
INDOOR RADON EXPOSURE AND ACTIVE AND PASSIVE SMOKING IN RELATION TO THE OCCURRENCE OF LUNG-CANCER
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DOI：
10.5271/sjweh.1918
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发表时间：
1988-10-01
影响因子：
6.3
通讯作者：
WINGREN, G
中科院分区：
文献类型：
--
作者：
AXELSON, O;ANDERSSON, K;WINGREN, G
目前，暴露于室内氡气和氡子体作为肺癌的可能原因引起了人们的极大兴趣。这一担忧得到了多项研究的支持，其中大多数研究的数量相对较少，或者暴露评估较弱。这项研究涵盖了 177 名肺癌患者和 677 名非癌症患者，他们均已去世，并且在瑞典南部中部有氡气泄漏明矾页岩沉积物的地区的同一所房子里居住了 30 年或以上。创建了基于建筑材料、房屋类型和地面条件的暴露类别，同时还对 142 个案例和 264 个参考对象进行了室内氡气子体浓度的测量。通过向近亲发送调查问卷来确定主动吸烟和被动吸烟。总体而言，就假设的农村人口氡子体暴露类别而言，肺癌风险约为两倍，但对于城市地区的同一类别而言，肺癌风险并非如此，这可能是由于暴露评估不太精确和其他因素的影响。偶尔吸烟者和被动吸烟者，以及单独吸烟者，与暴露类别的增加相关，患肺癌的风险尤其增加。
Exposure to indoor radon and radon daughters is currently attracting great interest as a possible cause of lung cancer. This concern is supported by several studies, most of them relatively small in numbers or weak in the assessment of exposure. This study encompasses 177 persons with lung cancer and 677 noncancer referents, all deceased and with 30 years or more of residency in the same house in an area with radon-leaking alum shale deposits in the central part of southern Sweden. Exposure categories based on building material, type of house, and ground conditions were created, but measurements of the indoor radon daughter concentration were also made for 142 cases and 264 referents. Active and passive smoking was ascertained through questionnaires sent to the next-of-kin. Overall, the lung cancer risk was approximately twofold with regard to the categories of assumed radon daughter exposure for the rural sector of the population but not for the same categories of the urban sector, possibly because of less precise exposure assessment and influence form other factors. Occasional and passive smoker, as well as passive smokers alone, had a particularly increased risk of lung cancer in association with the increased exposure categories.