EFFECTS OF AGING ON ENZYME-HISTOCHEMICAL, MORPHOMETRICAL AND CONTRACTILE PROPERTIES OF THE SOLEUS MUSCLE IN THE RAT
EFFECTS OF AGING ON ENZYME-HISTOCHEMICAL, MORPHOMETRICAL AND CONTRACTILE PROPERTIES OF THE SOLEUS MUSCLE IN THE RAT
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DOI：
10.1016/0022-510x(89)90165-2
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发表时间：
1989-10-01
影响因子：
4.4
通讯作者：
LARSSON, L
中科院分区：
文献类型：
--
作者：
ANSVED, T;LARSSON, L
本文对2-25月龄雄性Wistar大鼠比目鱼肌慢缩肌的酶组织化学、形态计量学和生理特性进行了研究。有一个明确的年龄相关的转变，在酶组织化学的肌肉，从快收缩肌纤维转化为慢收缩肌纤维。这一过程发生在7-8个月大的年轻动物中。在年龄较大的纤维总数略有减少，萎缩和角纤维的发病率增加，表明去神经过程。强直力随着年龄的增长而降低，但当它与总肌纤维横截面积相关时，没有发现与年龄相关的差异。收缩时间仅在20-25月龄的动物中显着改变，在那里它被延长，而半松弛时间在整个年龄跨度中表现出延长的趋势。因此，残余收缩材料的力产生能力不受年龄的显著影响，并且与年龄相关的快缩肌纤维数量减少不是收缩速度降低的重要因素。
Enzyme-histochemical, morphometrical and physiological properties were studied in the slow-twitch soleus muscle of male Wistar rats 2-25 months old. There was a clear age-related shift in the enzyme-histochemical profile of the muscle, resulting from transformation of fast-twitch muscle fibres to slow-twitch ones. This process occurred in younger animals up to the age of 7-8 months. At older ages there was a slight reduction in the total number of fibres and an increasing incidence of atrophic and angular fibres, indicating a denervation process. The tetanus force was reduced with age, but when it was related to the total muscle fibre cross-sectional area, no age-related difference was found. The contraction time was significantly altered only in 20-25-month-old animals, where it was prolonged, whereas the half-relaxation time showed a tendency towards prolongation throughout the entire age-span. Thus, the force-generating capacity of residual contractile material was not significantly affected by age and the age-associated decrease in the number of fast-twitch muscle fibres was not an important contributing factor to the decreased speed of contraction.