Electroacupuncture most effectively elicits depressor and bradycardic responses at 1 Hz in humans
Electroacupuncture most effectively elicits depressor and bradycardic responses at 1 Hz in humans
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DOI：
10.1007/s10286-015-0330-x
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发表时间：
2016-02-01
影响因子：
5.8
通讯作者：
Miyamoto, Tadayoshi
中科院分区：
文献类型：
--
作者：
Nakahara, Hidehiro;Kawada, Toru;Miyamoto, Tadayoshi
针刺刺激作用于自主神经系统，引起抑制和心动过缓的作用。然而，以往的人体研究并没有对针刺的最佳条件进行定量分析，如刺激频率和持续时间，以达到最大的降压和心动过缓的效果。本研究的目的是研究不同的电针刺激频率对人类血压和心率随时间变化的影响。12名健康志愿者参加了这项研究。在前臂前侧的西门穴（WHO命名法PC4）插入一根针灸针。电刺激强度为1 V，脉宽为5 ms，刺激频率为0.5、1、5、10 Hz，电刺激顺序随机。电针持续时间为6分钟，在此期间监测血压和心率反应。组平均数据显示，1hz电针可降低血压和心率。1 hz电针治疗4 ~ 6 min时，血压由刺激前基线值86.6 +/- A 2.9降至81.4 +/- A 2.3 mmHg（平均+/- A SE， P < 0.01）。心率也显著降低（由66.2 +/- A 2.0降至62.7 +/- A 1.7, P < 0.01）。这些结果提供了基本证据，证明电针可有效地在人体中产生心动过缓和抑制反应。
Acupuncture stimulation is known to act on the autonomic nervous system and elicits depressor and bradycardic effects. However, previous studies on humans did not conduct quantitative analyses on optimal acupuncture conditions such as the stimulation frequency and duration to achieve maximum depressor and bradycardic effects. The aim of the present study was to investigate the effects of varying stimulation frequencies of electroacupuncture on time-dependent changes in blood pressure and heart rate in humans.Twelve healthy volunteers participated in the study. An acupuncture needle was inserted at the Ximen acupoint (PC4 according to WHO nomenclature), located at the anterior aspect of the forearm. An electrical stimulation was delivered through the acupuncture needle at an intensity of 1 V, pulse width of 5 ms, and stimulation frequencies of 0.5, 1, 5, and 10 Hz in a random order. The duration of electroacupuncture was 6 min, during which blood pressure and heart rate responses were monitored.Group-averaged data indicated that 1-Hz electroacupuncture decreased blood pressure and heart rate. Blood pressure was significantly decreased from the prestimulation baseline value of 86.6 +/- A 2.9 to 81.4 +/- A 2.3 mmHg during 4-6 min of 1-Hz electroacupuncture (mean +/- A SE, P < 0.01). Heart rate was also significantly decreased (from 66.2 +/- A 2.0 to 62.7 +/- A 1.7 beats/min, P < 0.01).These results provide fundamental evidence that bradycardiac and depressor responses are effectively produced by electrical acupuncture in humans.