GLUCOCORTICOIDS INDUCE THE FORMATION AND RELEASE OF ANTI‐INFLAMMATORY AND ANTI‐PHOSPHOLIPASE PROTEINS INTO THE PERITONEAL CAVITY OF THE RAT
GLUCOCORTICOIDS INDUCE THE FORMATION AND RELEASE OF ANTI‐INFLAMMATORY AND ANTI‐PHOSPHOLIPASE PROTEINS INTO THE PERITONEAL CAVITY OF THE RAT
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糖皮质激素诱导大鼠腹腔内抗炎和抗磷脂酶蛋白的形成和释放
DOI：
10.1111/j.1476-5381.1982.tb09205.x
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发表时间：
1982
影响因子：
7.3
通讯作者：
D. Stone
中科院分区：
文献类型：
--
作者：
Black Gj;R. Carnuccio;M. Rosa;R. Flower;C.S.J. Langham;L. Parente;P. Persico;N. Russell;D. Stone
1地塞米松和氢化可的松可诱导大鼠腹膜腔释放抗磷脂酶蛋白。2促肾上腺皮质激素(ACTH)在正常大鼠也释放这些蛋白，但在肾上腺切除大鼠则不释放。3采用离子交换和尺寸排斥层析分离腹膜灌洗液蛋白。抗磷脂酶活性存在于四个不同的组分中，主要组分具有明显的摩尔分数。含有这些抗磷脂酶蛋白的40k.4柱级分在大鼠角叉菜胶胸膜炎模型中有抗炎作用，而其他组分则没有活性。5这些蛋白质似乎与糖皮质激素作用于花生四烯酸系统的“第二信使”--大皮质素和脂调节蛋白相同。
1 Dexamethasone and hydrocortisone induce the release of anti‐phospholipase proteins into the peritoneal cavities of rats. 2 Adrenocorticotropic hormone (ACTH) also releases these proteins in normal but not in adrenalectomized rats. 3 Peritoneal lavage proteins were separated by ion‐exchange and size exclusion chromatography. The anti‐phospholipase activity occurred in four separate fractions with the major component having an apparent mol. wt. of 40 k. 4 Column fractions containing these anti‐phospholipase proteins had anti‐inflammatory effects in the rat carrageenin pleurisy model whereas other fractions were inactive. 5 The proteins appear to be identical to macrocortin and lipomodulin, the ‘second messengers’ of glucocorticoid hormone action on the arachidonate system.