Experience-dependent, asymmetric expansion of hippocampal place fields
Experience-dependent, asymmetric expansion of hippocampal place fields
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DOI：
10.1073/pnas.94.16.8918
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发表时间：
1997-08-05
影响因子：
11.1
通讯作者：
McNaughton, BL
中科院分区：
文献类型：
--
作者：
Mehta, MR;Barnes, CA;McNaughton, BL
基于时间不对称性的序列学习理论，Hebbian长时程增强预测，在路线学习期间，海马神经元的空间放电分布应该在与动物运动相反的方向上扩大，在路线AB上，来自代表A的细胞的突触驱动增加将导致代表B的细胞更早和更强烈地放电，这些效应在大鼠在封闭轨道上跑几圈内出现，这为赫布突触可塑性提供了间接证据，并从功能上解释了为什么位置细胞在路线追踪过程中具有方向选择性，即保持编码序列方向所必需的突触不对称性。
Theories of sequence learning based on temporally asymmetric, Hebbian long-term potentiation predict that during route learning the spatial firing distributions of hippocampal neurons should enlarge in a direction opposite to the animal's movement, On a route AB, increased synaptic drive from cells representing A would cause cells representing B to fire earlier and more robustly, These effects appeared within a few laps in rats running on closed tracks, This provides indirect evidence for Hebbian synaptic plasticity and a functional explanation for why place cells become directionally selective during route following, namely, to preserve the synaptic asymmetry necessary to Encode the sequence direction.