Establishment and maintenance of blood-lymph separation.
Establishment and maintenance of blood-lymph separation.
复制标题
血淋巴分离的建立和维持。
DOI：
10.1007/s00018-019-03042-3
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Trivedi,ChinmayM
中科院分区：
文献类型：
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作者：
Janardhan,HarishP;Trivedi,ChinmayM
希波克拉底语料库是希腊医学文献集，描述了公元前五世纪淋巴系统的功能解剖学。随后对尸体和手术患者的研究证实，淋巴管将外渗的间质液（也称为淋巴液）排入双侧淋巴静脉交界处的静脉系统。最近的进展表明，淋巴静脉瓣膜和淋巴静脉连接处血小板介导的止血作用可维持血液和淋巴血管系统的终生分离。在这里，我们回顾了表现出血液-淋巴分离失败的小鼠模型，以强调调节淋巴疾病的新机制和分子靶点。具体来说，我们关注调节淋巴静脉瓣膜发育和血小板介导的淋巴静脉止血的转录因子、辅助因子和信号通路，它们共同维持血液-淋巴分离。
Hippocratic Corpus, a collection of Greek medical literature, described the functional anatomy of the lymphatic system in the fifth century B.C. Subsequent studies in cadavers and surgical patients firmly established that lymphatic vessels drain extravasated interstitial fluid, also known as lymph, into the venous system at the bilateral lymphovenous junctions. Recent advances revealed that lymphovenous valves and platelet-mediated hemostasis at the lymphovenous junctions maintain life-long separation of the blood and lymphatic vascular systems. Here, we review murine models that exhibit failure of blood–lymph separation to highlight the novel mechanisms and molecular targets for the modulation of lymphatic disorders. Specifically, we focus on the transcription factors, cofactors, and signaling pathways that regulate lymphovenous valve development and platelet-mediated lymphovenous hemostasis, which cooperate to maintain blood–lymph separation.