Curcumin Ameliorates Lead (Pb2+)-Induced Hemato-Biochemical Alterations and Renal Oxidative Damage in a Rat Model
Curcumin Ameliorates Lead (Pb2+)-Induced Hemato-Biochemical Alterations and Renal Oxidative Damage in a Rat Model
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DOI：
10.1007/s12011-015-0360-1
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发表时间：
2015-11-01
影响因子：
3.9
通讯作者：
Sadek, Ismail A.
中科院分区：
文献类型：
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作者：
Abdel-Moneim, Ashraf M.;El-Toweissy, Mona Y.;Sadek, Ismail A.
本研究旨在评价姜黄素（Curc）对醋酸铅[Pb（CH 3COO）（2）center dot 3 H2O]处理诱导的血液学和生化变化以及肾脏病理的保护作用。将雄性白化病大鼠用Pb 2+（25 mg醋酸铅/kg b.w.，一天一次）或与Curc（30 mg Curc/kg b.w.，每天两次），持续7天。大鼠暴露于Pb 2+引起血红蛋白（Hb）含量，红细胞压积（Ht）值，血小板（Plt）计数显着下降，而Pb 2+相关的白细胞增多症伴随着绝对嗜中性粒细胞增多症，单核细胞增多症，淋巴细胞减少症，嗜酸性粒细胞减少症。与对照组相比，铅组大鼠肾脏、肝脏和血清中脂质过氧化（LPO）显著升高，总抗氧化能力（TAC）显著下降。此外，注射Pb 2+后，血液中的总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平显著升高，血清高密度脂蛋白（HDL-C）水平急剧下降。此外，肝肾功能检查增强。同时，Pb ~（2+）引起肾皮质组织细胞学改变。对Pb 2+给药动物联合给予Curc后，上述大部分参数恢复至接近正常水平/特征。总之，Curc似乎是一种有前途的药物，对铅诱导的毒性保护。
This study aims to evaluate the protective role of curcumin (Curc) against hematological and biochemical changes, as well as renal pathologies induced by lead acetate [Pb (CH3COO)(2)center dot 3H2O] treatment. Male albino rats were intraperitoneally treated with Pb2+ (25 mg of lead acetate/kg b.w., once a day) alone or in combination with Curc (30 mg of Curc/kg b.w., twice a day) for 7 days. Exposure of rats to Pb2+ caused significant decreases in hemoglobin (Hb) content, hematocrit (Ht) value, and platelet (Plt) count, while Pb2+-related leukocytosis was accompanied by absolute neutrophilia, monocytosis, lymphopenia, and eosinopenia. A significant rise in lipid peroxidation (LPO) and a marked drop of total antioxidant capacity (TAC) were evident in the kidney, liver, and serum of Pb2+ group compared to that of control. Furthermore, significantly high levels of total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C), and a sharp drop in serum high-density lipoprotein (HDL-C) level were also seen in blood after injection of Pb2+. Additionally, hepatorenal function tests were enhanced. Meanwhile, Pb2+ produced marked histo-cytological alterations in the renal cortex. Co-administration of Curc to the Pb2+-treated animals restored most of the parameters mentioned above to near-normal levels/features. In conclusion, Curc appeared to be a promising agent for protection against Pb2+-induced toxicity.