Neural and head induction by insulin-like growth factor signals
Neural and head induction by insulin-like growth factor signals
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DOI：
10.1016/s1534-5807(01)00069-7
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发表时间：
2001-11-01
影响因子：
11.8
通讯作者：
De Robertis, EM
中科院分区：
文献类型：
--
作者：
Pera, EM;Wessely, O;De Robertis, EM
证据提出了一个新的途径参与前神经发育。研究发现，IGF结合蛋白5（IGFBP-5），以及三个IGF在早期胚胎中表达，促进前部发育，增加头部区域的代价在mRNA注射非洲爪蟾胚胎的躯干。分泌的显性阴性I型IGF受体（DN-IGFR）具有相反的作用。IGF mRNA导致诱导异位眼和含有脑组织的异位头样结构。在外胚层外植体中，IGF信号诱导前神经标记物在中胚层形成和DN-IGFR抑制神经诱导的BMP拮抗剂Chordin的情况下。因此，活跃的IGF信号似乎是非洲爪蟾前神经诱导所需的和足够的。
Evidence is presented for a new pathway participating in anterior neural development. It was found that IGF binding protein 5 (IGFBP-5), as well as three IGFs expressed in early embryos, promoted anterior development by increasing the head region at the expense of the trunk in mRNA-injected Xenopus embryos. A secreted dominant-negative type I IGF receptor (DN-IGFR) had the opposite effect. IGF mRNAs led to the induction of ectopic eyes and ectopic head-like structures containing brain tissue. In ectodermal explants, IGF signals induced anterior neural markers in the absence of mesoderm formation and DN-IGFR inhibited neural induction by the BMP antagonist Chordin. Thus, active IGF signals appear to be both required and sufficient for anterior neural induction in Xenopus.