The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster
The neuroarchitecture of the circadian clock in the brain of Drosophila melanogaster
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DOI：
10.1002/jemt.10357
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发表时间：
2003-10-01
影响因子：
2.5
通讯作者：
Helfrich-Förster, C
中科院分区：
文献类型：
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作者：
Helfrich-Förster, C
神经行为学家试图将行为功能分配给特定的大脑中心，如果可能的话，将其分配给单个神经元和特定基因的表达。该方法已成功应用于果蝇的昼夜节律行为控制。一些所谓的“时钟基因”在大脑外侧和背侧的特定神经元中表达，在那里它们产生细胞自主的分子昼夜节律振荡。这些集群相互连接，对行为节律的控制有不同的贡献。本报告回顾了果蝇大脑中控制活动和蛹羽化的个体昼夜节律起搏器神经元的最新研究成果，并提出了它们与外部光暗周期同步的神经元途径，以及它们如何对行为施加周期性的问题。(C) 2003 Wiley-Liss, Inc。
Neuroethologists try to assign behavioral functions to certain brain centers, if possible down to individual neurons and to the expression of specific genes. This approach has been successfully applied for the control of circadian rhythmic behavior in the fruit fly Drosophila melanogaster. Several so-called "clock genes" are expressed in specific neurons in the lateral and dorsal brain where they generate cell-autonomous molecular circadian oscillations. These clusters are connected with each other and contribute differentially to the control of behavioral rhythmicity. This report reviews the latest work on characterizing individual circadian pacemaker neurons in the fruit fly's brain that control activity and pupal eclosion, leading to the questions by which neuronal pathways they are synchronized to the external light-dark cycle, and how they impose periodicity on behavior. (C) 2003 Wiley-Liss, Inc.