Quantification of nicotinic acetylcholine receptors in Parkinson's disease with 123I-5IA SPECT
Quantification of nicotinic acetylcholine receptors in Parkinson's disease with 123I-5IA SPECT
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DOI：
10.1016/j.jns.2007.02.014
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发表时间：
2007-05-15
影响因子：
4.4
通讯作者：
Fukuyama, Hidenao
中科院分区：
文献类型：
--
作者：
Oishi, Naoya;Hashikawa, Kazuo;Fukuyama, Hidenao
我们量化了帕金森病（PD）患者体内脑烟碱乙酰胆碱受体（nAChR）的分布，并评估了nAChR分布与患者临床变量（尤其是多巴胺能药物）之间的相关性。对10例无痴呆的PD患者进行了5-I-123-碘-3-（2（S）-氮杂环丁烷甲氧基）吡啶（I-123- 51 A）单光子发射计算机断层扫描（SPECT），并与10例年龄匹配的健康志愿者进行比较。并对患者各脑区I-123-5IA分布量与临床变量进行相关性分析。与对照组相比，PD组的脑干和额叶皮质出现统计学显著性降低（20-25%）。尽管年龄、病程、左旋多巴日剂量、PD用药时间和统一帕金森病评定量表运动部分评分与任何脑区DV值均无显著相关性，但高剂量多巴胺激动剂日剂量与小脑、颞叶、顶叶和枕叶皮质DV呈显著负相关。这些发现表明，没有痴呆的PD患者可以表现出减少，特别是在脑干和额叶皮层。他们还表明，多巴胺激动剂可能对nAChR的分布产生负面影响。(C)2007 Elsevier B. V.保留所有权利。
We quantified in vivo brain nicotinic acetylcholine receptor (nAChR) distributions in patients with Parkinson's disease (PD) and evaluated correlations between nAChR distributions and clinical variables of the patients, especially dopaminergic medications. Ten patients with PD without dementia underwent 5-I-123-iodo-3-(2(S)-azetidinylmethoxy)pyridine (I-123-51A) single photon emission computed tomography (SPECT) and the data were compared with those of 10 age-matched healthy volunteers. Correlation analyses between I-123-5IA distribution volumes (DVs) in each brain region and clinical variables of the patients were also performed. The PD group showed a statistically significant decrease (20-25%) in the brainstem and frontal cortex as compared with the control group. Although age, duration of disease, daily dose of levodopa, duration of PD medication use, and scores on the motor section of Unified Parkinson's Disease Rating Scale were not significantly correlated with DV values in any brain regions, high daily doses of dopamine agonist showed a significant negative correlation with DVs in the cerebellum, and temporal, parietal and occipital cortices. These findings suggest that patients with PD without dementia can show reductions especially in the brainstem and frontal cortex. They also suggest that dopamine agonists can have a negative influence on the distribution of nAChRs. (C) 2007 Elsevier B.V. All rights reserved.