Atypical development of the central auditory system in young children with Autism spectrum disorder.
Atypical development of the central auditory system in young children with Autism spectrum disorder.
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患有自闭症谱系障碍的幼儿中枢听觉系统的非典型发育。
作者：
Yoshimura;Y.;Kikuchi;M.;Hiraishi;H.;Hasegawa;C.;Takahashi;T.;Remijn;G. B.;Oi;M.;Munesue;T.;Higashida;H.;Minabe;Y.;Kojima;H.
听觉诱发磁场的P1 m成分是与语言习得相关的最早的皮层反应。然而，P1 m组分的生长曲线在典型发育（TD）和发育不良的儿童中是未知的。本研究的目的是澄清该组件的发展模式时，诱发双耳人类语音刺激使用儿童定制的脑磁图。共有35名年幼的TD儿童（32-121个月）和35名自闭症谱系障碍（ASD）儿童（38-111个月）参加了这项研究。这是第一份证明TD儿童左半球P1 m偶极子强度呈倒U形增长曲线的报告。此外，我们的研究结果揭示了3至9岁ASD儿童听觉脑反应的年龄相关分布更加多样化。这些结果证明了ASD中P1 m成分在幼儿期的多样化增长曲线，这是第一语言习得的关键时期。Autism Res 2016，9：1216-1226。© 2016国际自闭症研究学会，Wiley Periodicals，Inc.
The P1m component of the auditory evoked magnetic field is the earliest cortical response associated with language acquisition. However, the growth curve of the P1m component is unknown in both typically developing (TD) and atypically developing children. The aim of this study is to clarify the developmental pattern of this component when evoked by binaural human voice stimulation using child‐customized magnetoencephalography. A total of 35 young TD children (32–121 months of age) and 35 children with autism spectrum disorder (ASD) (38–111 months of age) participated in this study. This is the first report to demonstrate an inverted U‐shaped growth curve for the P1m dipole intensity in the left hemisphere in TD children. In addition, our results revealed a more diversified age‐related distribution of auditory brain responses in 3‐ to 9‐year‐old children with ASD. These results demonstrate the diversified growth curve of the P1m component in ASD during young childhood, which is a crucial period for first language acquisition.Autism Res2016, 9: 1216–1226. © 2016 International Society for Autism Research, Wiley Periodicals, Inc.