Prepulse inhibition of acoustic startle in subjects with schizophrenia treated with olanzapine or haloperidol
Prepulse inhibition of acoustic startle in subjects with schizophrenia treated with olanzapine or haloperidol
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DOI：
10.1016/s0165-1781(03)00161-6
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发表时间：
2003-08-30
影响因子：
11.3
通讯作者：
Rotrosen, J
中科院分区：
文献类型：
--
作者：
Duncan, E;Szilagyi, S;Rotrosen, J
研究的声音惊吓反应和其抑制的介绍了一个非惊人的初步刺激（前脉冲抑制，PPI）显示赤字PPI在精神分裂症的受试者相比，健康对照。动物研究表明，非典型抗精神病药物改善PPI赤字诱导的NMDA拮抗剂比典型的抗精神病药物更一致。在文献中，药物状态对精神分裂症患者PPI的影响尚未解决。在本研究中，在精神分裂症受试者中比较了非典型抗精神病药奥氮平和典型抗精神病药氟哌啶醇与未用药状态对PPI的影响。在组间设计中，11例接受奥氮平治疗的精神分裂症受试者、16例接受氟哌啶醇治疗的受试者和14例未接受药物治疗的受试者接受了声惊吓试验和PPI测定。方差分析显示，奥氮平、氟哌啶醇和未用药组之间的惊吓单独脉冲刺激、惊吓习惯或PPI无显著差异。将这41名精神分裂症受试者与21名历史健康对照组进行比较，发现PPI降低。这些数据并未表明奥氮平与氟哌啶醇相比对精神分裂症患者感觉运动门控的优先效应。结果与PPI损伤在治疗条件下相对稳定的假设一致。(C)2003爱思唯尔爱尔兰有限公司保留所有权利。
Studies of the acoustic startle response and of its inhibition by the presentation of a non-startling preliminary stimulus (prepulse inhibition, PPI) have revealed deficits in PPI in schizophrenic subjects compared to healthy controls. Animal studies indicate that atypical antipsychotics improve PPI deficits induced by NMDA antagonists more consistently than typical antipsychotics. The effect of medication status on PPI in schizophrenia is unresolved in the literature. In the current study the effects on PPI of the atypical antipsychotic olanzapine and the typical antipsychotic haloperidol were compared to the unmedicated state in subjects with schizophrenia. In a between-group design, 11 schizophrenic subjects on olanzapine, 16 subjects on haloperidol, and 14 subjects who were on no medication received acoustic startle testing with PPI determination. ANOVAs revealed no significant differences in startle to pulse alone stimuli, habituation of startle, or PPI between the olanzapine, haloperidol and unmedicated groups. These 41 subjects with schizophrenia were compared to a group of 21 historical healthy controls and found to have reduced PPI. These data do not indicate a preferential effect of olanzapine compared to haloperidol on sensorimotor gating in schizophrenia. The results are consistent with the hypothesis that PPI impairments are relatively stable across treatment conditions. (C) 2003 Elsevier Ireland Ltd. All rights reserved.