Defects generated in human stratum corneum specimens by ultrasound
Defects generated in human stratum corneum specimens by ultrasound
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DOI：
10.1016/s0301-5629(98)00049-0
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发表时间：
1998-06-01
影响因子：
2.9
通讯作者：
Weimann, L
中科院分区：
文献类型：
--
作者：
Wu, JR;Chappelow, J;Weimann, L
在过去的二十年中，超声（US）已被应用于增强经皮药物递送，这种方法被称为超声促渗（sonophoresis），其增强的物理机制远未完全理解，在我们的研究中已经表明，168-kHz连续US的空间平均压力振幅为1.9 × 10（5）Pa，诱导了新的结构状态并产生了缺陷（截留的气穴）。发现缺陷的尺寸为约20 μ m，大到足以允许通常避开未增强的经皮药物递送的高分子量药物分子的经皮通过。(C)1998年世界医学和生物学超声联合会。
Over the last two decades, ultrasound (US) has been applied to enhance transdermal drug delivery, This method is called sonophoresis, The physical mechanism of the enhancement is far from being fully understood, It has been shown in our study that 168-kHz continuous US of spatially averaged pressure amplitude of 1.9 x 10(5) Pa induced a new structural state and generated defects (entrapped air pockets) in human stratum corneum specimens. The dimensions of the defects were found to be about 20 mu m, large enough to allow the transdermal passage of high-molecular-weight drug molecules that normally elude the unenhanced transdermal drug delivery. (C) 1998 World Federation for Ultrasound in Medicine & Biology.