Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging.
Regeneration, Rejuvenation, and Replacement: Turning Back the Clock on Tissue Aging.
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DOI：
10.1101/cshperspect.a040907
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发表时间：
2021-09-01
影响因子：
7.2
通讯作者：
Jones DL
中科院分区：
文献类型：
--
作者：
Rando TA;Jones DL
虽然有些动物，如涡虫和水螅，似乎能够无限循环地再生，但大多数动物的适应性逐渐下降，最终死亡。细胞和组织功能的逐渐丧失，导致衰老和死亡，通常被称为衰老。成体（“组织”）干细胞维持组织稳态并促进修复；然而，随着时间的推移，与年龄相关的干细胞功能变化是老年人器官功能丧失或疾病的主要原因。因此，在恢复干细胞功能以对抗退行性疾病和与年龄相关的组织功能障碍方面投入了相当大的努力。在这里，我们将回顾可用于恢复干细胞功能的策略，包括使用环境干预，如饮食和锻炼，异慢性方法和细胞重编程。在晚年保持最佳的干细胞功能和组织稳态可能会延长老年人独立和健康生活的时间。
While some animals, such as planaria and hydra, appear to be capable of seemingly endless cycles of regeneration, most animals experience a gradual decline in fitness and ultimately die. The progressive loss of cell and tissue function, leading to senescence and death, is generally referred to as aging. Adult (‘tissue’) stem cells maintain tissue homeostasis and facilitate repair; however, age-related changes in stem cell function over time are major contributors to loss of organ function or disease in older individuals. Therefore, considerable effort is being invested in restoring stem cell function to counter degenerative diseases and age-related tissue dysfunction. Here, we will review strategies that could be used to restore stem cell function, including the use of environmental interventions, such as diet and exercise, heterochronic approaches and cellular reprogramming. Maintaining optimal stem cell function and tissue homeostasis into late life will likely extend the amount of time older adults are able to be independent and lead healthy lives.
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影响因子：
4.5
作者：
Biteau B;Karpac J;Supoyo S;Degennaro M;Lehmann R;Jasper H
通讯作者：
Jasper H
影响因子：
64.8
作者：
Abad, Maria;Mosteiro, Lluc;Serrano, Manuel
通讯作者：
Serrano, Manuel
影响因子：
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Jones, D. Leanne;Rando, Thomas A.
通讯作者：
Rando, Thomas A.
影响因子：
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Egerman MA;Cadena SM;Gilbert JA;Meyer A;Nelson HN;Swalley SE;Mallozzi C;Jacobi C;Jennings LL;Clay I;Laurent G;Ma S;Brachat S;Lach-Trifilieff E;Shavlakadze T;Trendelenburg AU;Brack AS;Glass DJ
通讯作者：
Glass DJ
影响因子：
29
作者：
Jasper H;Jones DL
通讯作者：
Jones DL