Growth factor regulated expression of poly(A)+ binding protein messenger RNA.
Growth factor regulated expression of poly(A)+ binding protein messenger RNA.
复制标题
生长因子调节 Poly(A) 结合蛋白信使 RNA 的表达。
DOI：
10.1016/0014-4827(89)90109-2
复制
发表时间：
1989
影响因子：
3.7
通讯作者：
Shields,MT
中科院分区：
文献类型：
--
作者：
Mercer,WE;Jaskulski,D;Shields,MT
A 72,000 mol wt protein designated PABP binds to the poly(A)+track of messenger RNAs with high affinity and has been suggested to play an important role in mRNA metabolism in eucaryotic cells. We have employed a human PABP cDNA probe to study the expression of this gene at the mRNA level in BALB/c3T3 mouse cells under different growth conditions and in exponentially growing HeLa cells throughout the cell division cycle. We describe experiments which establish that in BALB/c3T3 cells the expression of this gene is growth factor regulated. Moreover, the gene behaves like a primary response gene in that its induction in quiescent cells does not require the prior synthesis of other growth factor-regulated proteins. In exponentially growing HeLa cells PABP mRNA is expressed throughout the cell division cycle indicating that the expression of this gene is not limited to a specific phase of the cell cycle.
