Production of Antibiotic Nanoparticles Using Supercritical CO2 as Antisolvent with Enhanced Mass Transfer
Production of Antibiotic Nanoparticles Using Supercritical CO2 as Antisolvent with Enhanced Mass Transfer
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DOI：
10.1021/ie010040r
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发表时间：
2001-07
影响因子：
4.2
通讯作者：
P. Chattopadhyay;Ram B. Gupta
中科院分区：
文献类型：
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作者：
P. Chattopadhyay;Ram B. Gupta
药物输送系统根据人体需求和作用部位以可控的速率输送药物，从而提高药物的治疗效果和安全性。这些系统有助于减少所需的药物量、剂量、副作用和生物失活。目前，利用纳米药物靶向和控释药物的递送系统正在被开发。一些技术，如喷雾干燥和碾磨，在过去已经被用于制造药物纳米颗粒，但是这些方法有几个缺点。超临界流体技术如RESS和SAS确实为颗粒形成提供了新的方法，但在大多数情况下，它们仍然不能产生药物靶向和控释所需的纳米范围（<300 nm）的颗粒。在这项工作中，我们提出了一种可以在纳米范围内生产具有窄尺寸分布的药物颗粒的技术。这项新技术是对现有的SAS技术的改进。
Drug delivery systems improve the therapeutic efficacy and safety of drugs by delivering them at a controlled rate depending on the body requirements and the site of action. These systems aid in reducing the amount of drug required, the number of doses, side effects, and bioinactivation. Currently, delivery systems for drug targeting and controlled release are being developed using drug nanoparticles. Several techniques, such as spray drying and milling, have been used in the past for the manufacture of drug nanoparticles, but these methods have several disadvantages. Supercritical fluid technologies such as RESS and SAS do provide novel methods for particle formation, but in most cases, they still cannot produce particles in the nanometer range (<300 nm) necessary for drug targeting and controlled release. In this work, we propose a technique that can produce drug particles in the nanometer range with a narrow size distribution. This new technique is a modification of the currently existing SAS technique...