Abnormal migration of T lymphocyte clones.
Abnormal migration of T lymphocyte clones.
复制标题
T 淋巴细胞克隆的异常迁移。
作者：
M. Dailey;C. Fathman;E. Butcher;E. Pillemer;I. Weissman
几个体外T细胞克隆明显缺乏其归巢外周淋巴组织的能力。这被发现的同种异体反应性noncytolytic克隆，可溶性抗原（KLH）的特定线，和特异性同种异体细胞和Abelson病毒诱导的淋巴瘤细胞的细胞毒性克隆。这种异常的循环模式可能是由于缺乏高内皮微静脉（HEV）的淋巴细胞受体引起的，正如小鼠淋巴结和派伊尔集合淋巴结的冷冻切片中缺乏这些T细胞与HEV的结合所暗示的那样。正常淋巴细胞迁移所必需的表面受体的丧失可能因此改变过继转移的T细胞的体内功能。
Several in vitro T cell clones were markedly deficient in their ability to home to peripheral lymphoid tissue. This was found for an alloreactive noncytolytic clone, a soluble antigen- (KLH)specific line, and cytotoxic clones specific for allogeneic cells and for Abelson virus-induced lymphoma cells. This abnormal circulation pattern was probably caused by the lack of the receptors of the lymphocytes for high endothelial venules (HEV), as implied by the lack of binding of these T cells to HEV in frozen sections of mouse lymph node and Peyer's patches. The loss of surface receptors that are necessary for normal lymphocyte migration may thereby alter the in vivo function of adoptively transferred T cells.