TLS, EWS and TAF15: a model for transcriptional integration of gene expression
TLS, EWS and TAF15: a model for transcriptional integration of gene expression
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DOI：
10.1093/bfgp/ell015
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发表时间：
2006-03-01
期刊：
影响因子：
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通讯作者：
Hicks, Geoffrey G.
中科院分区：
文献类型：
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作者：
Law, Warren J.;Cann, Kendra L.;Hicks, Geoffrey G.
多功能蛋白表明，基因表达不是一系列从转录开始并最终将成熟mRNA传递到细胞质的区室化事件，而是转录、剪接、RNA代谢和亚细胞靶向翻译的综合途径。其中一个多功能家族是由rna结合蛋白TLS、EWS和TAF15组成的。这三种蛋白各自为致癌融合蛋白提供一个有效的转录激活域，这些融合基因的形成被认为是其相关癌症的主要原因。野生型TLS、EWS和TAF15除了在剪接和mRNA转运中具有众所周知的功能外，还可以作为经典的转录因子。TLS与应激反应蛋白YB-1之间的相互作用是这些蛋白如何诱导基因表达多方面变化的一个例子，因为它们可以相互作用诱导靶基因的转录和剪接变化。研究TLS、EWS和TAF15的多种功能将增强我们对基因表达的整体理解，也使我们能够更好地了解这些蛋白如何促进相关融合蛋白启动的致癌途径。
Multifunctional proteins are demonstrating that gene expression is not a series of compartmentalized events beginning with transcription and culminating in delivery of mature mRNA into the cytoplasm, but an integrated pathway of transcription, splicing, RNA metabolism and subcellular targeting of translation. One such multifunctional family is made up of the RNA-binding proteins TLS, EWS and TAF15. These three proteins each contribute a potent transcriptional activation domain to oncogenic fusion proteins, and the formation of these fusion genes are thought to be the primary causes of their associated cancers. Wild-type TLS, EWS and TAF15 can function as classical transcription factors in addition to their better-known functions in splicing and mRNA transport. The interaction between TLS and the stress-response protein YB-1 is an example of how these proteins can induce a multi-faceted change in gene expression, as they can interact to induce changes in both transcription and splicing of target genes. Investigating the multiple functions of TLS, EWS and TAF15 will enhance our understanding of gene expression as a whole, and also allow us to better understand how these proteins may be contributing to the oncogenic pathways the associated fusion proteins initiate.