SYSTEMIC LUPUS-ERYTHEMATOSUS - PREDISPOSITION FOR UTERINE CERVICAL DYSPLASIA
SYSTEMIC LUPUS-ERYTHEMATOSUS - PREDISPOSITION FOR UTERINE CERVICAL DYSPLASIA
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DOI：
10.1177/096120339400300112
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发表时间：
1994-02-01
期刊：
影响因子：
2.6
通讯作者：
SCHARF, Y
中科院分区：
文献类型：
--
作者：
BLUMENFELD, Z;LORBER, M;SCHARF, Y
先前的一项回顾性研究发现，接受过细胞毒性药物治疗的系统性红斑狼疮(SLE)女性患宫颈异型性的风险增加。我们的目标是前瞻性地揭示SLE患者宫颈异型性的增加，并评估其与既往化疗的关系。共有39名系统性红斑狼疮妇女被前瞻性地转介进行宫颈细胞学PAP涂片检查。SLE妇女宫颈异型性的发生率(35.9%)显著高于非SLE对照组(小于或等于5%；P<；0.01)。以前接受细胞毒性药物如环磷酰胺或甲氨蝶呤治疗的患者的异型性发生率(4/9)与未接受细胞毒性药物治疗的系统性红斑狼疮患者(10/30)之间没有显著差异。镜下活检发现3例宫颈上皮内瘤变(CIN)I-III(23%)为异型性。我们的结论是，SLE妇女应该定期进行宫颈细胞学涂片检查，因为无论以前是否接受细胞毒治疗，异型性的发生率都会显著增加。
A previous retrospective study has found an increased risk of uterine cervical atypia in women with systemic lupus erythematosus (SLE) who have been treated with cytotoxic drugs. Our objective was to prospectively reveal any increased incidence of cervical atypia in SLE patients and to evaluate the relationship to previous chemotherapy. A total of 39 SLE women were prospectively referred for cytologic PAP smears of the uterine cervix. A significantly higher incidence of cervical atypia was found in SLE women (35.9%) compared with non-SLE control groups (less-than-or-equal-to 5%; P < 0.01). No significant difference was found between the incidence of atypia in patients previously treated by cytotoxic medications such as cyclophosphamide pulses or methotrexate (4 of 9) compared with SLE women not receiving cytotoxic drugs (10 of 30). Colposcopically directed biopsies revealed three cases of cervical intraepithelial neoplasia (CIN) I-III (23%) among the cases with atypia. We conclude that women with SLE should have regular cytologic cervical smears because of a significantly increased incidence of atypia, regardless of previous cytotoxic therapy.