External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.
External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database.
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使用国家电子健康记录数据库的数据对庆大霉素婴儿群体药代动力学模型进行外部评估。
DOI：
10.1128/aac.00669-18
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发表时间：
2018
影响因子：
4.9
通讯作者：
Gonzalez,Daniel
中科院分区：
文献类型：
--
作者：
Ge,Shufan;Beechinor,RyanJ;Hornik,ChristophP;Standing,JosephF;Zimmerman,Kanecia;Cohen-Wolkowiez,Michael;Laughon,MatthewM;Clark,Reese;Gonzalez,Daniel
庆大霉素是一种新生儿和婴儿常用的抗生素。最近发表的人口药代动力学(PK)模型是利用多项研究的数据开发的，我们分析的目的是评估使用国家电子健康记录(EHR)数据库对该模型进行进一步外部评估的可行性。我们的结果表明，在适当的数据捕获程序下，EHR数据可以作为PK模型外部评估的潜在数据源。
Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.