Disordered Iron Homeostasis in Chronic Heart Failure Prevalence, Predictors, and Relation to Anemia, Exercise Capacity, and Survival
Disordered Iron Homeostasis in Chronic Heart Failure Prevalence, Predictors, and Relation to Anemia, Exercise Capacity, and Survival
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DOI：
10.1016/j.jacc.2011.04.040
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发表时间：
2011-09-13
影响因子：
24
通讯作者：
Poole-Wilson, Philip A.
中科院分区：
文献类型：
--
作者：
Okonko, Darlington O.;Mandal, Amit K. J.;Poole-Wilson, Philip A.
目的全面了解慢性心力衰竭(CHF)患者铁代谢及其意义。背景铁缺乏是慢性心力衰竭(CHF)治疗的新靶点。方法对157例慢性心力衰竭(CHF)患者的铁和临床指标进行量化。首先，在贫血和非贫血受试者中，铁平衡紊乱，其特征是循环(转铁蛋白饱和度)和功能性(细胞平均血红蛋白浓度)铁状态减少，而面对似乎充足的铁储存(铁蛋白)。第二，虽然铁超载和铁储存增加的情况很少见(1%)，但铁缺乏(转铁蛋白饱和
Objectives The aim of this study was to comprehensively delineate iron metabolism and its implications in patients with chronic heart failure (CHF).Background Iron deficiency is an emerging therapeutic target in CHF.Methods Iron and clinical indexes were quantified in 157 patients with CHF.Results Several observations were made. First, iron homeostasis was deranged in anemic and nonanemic subjects and characterized by diminished circulating (transferrin saturation) and functional (mean cell hemoglobin concentration) iron status in the face of seemingly adequate stores (ferritin). Second, while iron overload and elevated iron stores were rare (1%), iron deficiency (transferrin saturation