Analysis of 142 Northern Chinese patients with peripheral T/NK-Cell lymphomas: subtype distribution, clinicopathologic features, and prognosis.
Analysis of 142 Northern Chinese patients with peripheral T/NK-Cell lymphomas: subtype distribution, clinicopathologic features, and prognosis.
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DOI：
10.1309/ajcpwkj3gpfrt7ga
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发表时间：
2012-09
影响因子：
3.5
通讯作者：
Ya-li Ren;L. Nong;Shuang Zhang;J. Zhao;Xiao-ming Zhang;Tingting Li
中科院分区：
文献类型：
--
作者：
Ya-li Ren;L. Nong;Shuang Zhang;J. Zhao;Xiao-ming Zhang;Tingting Li
外周T细胞和自然杀伤(NK)细胞淋巴瘤(PTNKL)是一组异质性淋巴系统恶性肿瘤。我们对142例进行了重新分类，并分析了它们的临床病理特征和转归。结果显示最常见的亚型为结外NK/T细胞淋巴瘤、鼻型(38.0%)、血管免疫母细胞性T细胞淋巴瘤(16.9%)和外周T细胞淋巴瘤(16.2%)。124例患者获得随访，总生存期为3天至134个月，中位数为11个月。多因素分析显示，血小板减少(P=.001)、乳酸脱氢酶升高(P=.007)、高Ki-67指数(P=.002)和超过20%的细胞中T-bet表达(P=.036)是所有病例的独立因素，其中只有T-bet因素表明预后良好，而对于Enk/T组，血小板减少(P=.011)和放射治疗(P=.026)是显著的。因此，Enk/T是该系列中最常见的亚型。T-bet在预测预后中的意义有待进一步证实。
Peripheral T- and natural killer (NK)-cell lymphomas (PTNKLs) are a heterogeneous group of lymphoid malignancies. We reclassified 142 cases and investigated their clinicopathologic features and outcome. Results showed that the most prevalent subtypes were extranodal NK/T-cell lymphoma, nasal type (eNK/T) (38.0%); angioimmunoblastic T-cell lymphoma (16.9%); and peripheral T-cell lymphoma, not otherwise specified (16.2%). Follow-up was available in 124 patients whose overall survival ranged from 3 days to 134 months, with a median of 11 months. Multivariate analysis demonstrated that thrombocytopenia (P = .001), elevated lactate dehydrogenase (P = .007), high Ki-67 index (P = .002), and T-bet expression in more than 20% of cells (P = .036) were independent factors for all cases-among which only the factor of T-bet indicated good outcome-and that thrombocytopenia (P = .011) and radiotherapy (P = .026) were significant for the eNK/T group. Thus, eNK/T was the commonest subtype in this series. The significance of T-bet in predicting outcome should be further confirmed.