Survey of genetic counselors and clinical geneticists' use and attitudes toward pharmacogenetic testing.
Survey of genetic counselors and clinical geneticists' use and attitudes toward pharmacogenetic testing.
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DOI：
10.1111/j.1399-0004.2012.01848.x
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发表时间：
2012-08
影响因子：
3.5
通讯作者：
Agans R
中科院分区：
文献类型：
--
作者：
Haga SB;O'Daniel JM;Tindall GM;Mills R;Lipkus IM;Agans R
药物遗传学(PGx)测试旨在通过根据患者无反应和/或不良事件的遗传风险进行量身定制的治疗来改善治疗结果。鉴于他们的专业知识，遗传学家可以促进PGx检测的使用；然而，临床遗传学社区的准备和所起的作用尚不清楚。为了评估遗传学家在提供PGx检测中的态度、准备和感知的角色，我们对1500名随机选择的美国委员会认证的遗传咨询师和临床遗传学家进行了调查(回复率：37.8%(n=516))。12%的遗传咨询师和41%的临床遗传学家表示，他们已经为PGx测试安排或协调了患者护理，在采用的早期阶段，这一比例似乎很高。几乎所有受访者都接受过药物遗传学方面的教育，尽管只有28%的咨询师和58%的临床遗传学家表示，他们对PGx检测感到知晓。约一半的咨询师(52%)和临床遗传学家(46%)认为他们会在提供PGx检测的过程中发挥一些作用；分别有17%和19%的人认为他们会起到不起作用或起到一点作用。在PGx检测的早期阶段，遗传学家和遗传顾问的角色尚不清楚。然而，他们的经验可能有助于为PGx测试做准备，并将交付策略告知临床实践。
Pharmacogenetic (PGx) testing aims to improve therapeutic outcomes through tailoring treatment based on a patient’s genetic risk for non-response and/or an adverse event. Given their expertise, geneticists could facilitate the use of PGx testing; however, , the preparedness and perceived role of the clinical genetics community is unclear. To assess the attitudes, preparedness, and perceived roles of geneticists in the delivery of PGx testing, we conducted a survey of 1500 randomly selected board-certified genetic counselors and clinical geneticists in the U.S (response rate: 37.8% (n=516)). Twelve percent of genetic counselors and 41% of clinical geneticists indicated that they had ordered or coordinated patient care for PGx testing, a seemingly high proportion at this early stage of adoption. Almost all respondents had some education on pharmacogenetics, though only 28% of counselors and 58% of clinical geneticists indicated they felt well-informed about PGx testing. About half of counselors (52%) and clinical geneticists (46%) felt they would play ‘some’ role in the delivery of PGx testing; 17% and 19%, respectively, felt that they would play ‘no’ or ‘a little’ role. At this early stage of PGx testing, the role of geneticists and genetic counselors is unclear. However, their experience may aid in readying PGx testing and informing delivery strategies into clinical practice.
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