Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese
Polymorphisms of cytochrome P450 1A1, glutathione S-transferase class mu, and tumour protein p53 genes and the risk of developing gallbladder cancer in Japanese
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DOI：
10.1016/j.clinbiochem.2007.04.005
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发表时间：
2007-08-01
影响因子：
2.8
通讯作者：
Yamamoto, Masaharu
中科院分区：
文献类型：
--
作者：
Tsuchiya, Yasuo;Kiyohara, Chikako;Yamamoto, Masaharu
目的：为研究细胞色素P450 1A 1（CYP 1A 1）、谷胱甘肽S转移酶mu（GSTM 1）和肿瘤蛋白p53（TP 53）基因多态性与胆囊癌（GBC）风险之间的关系，进行了一项病例对照研究。对54例GBC患者和178例对照者进行了CYP 1A 1 T3801 C、CYP 1A 1 Ile 462 VaI、GSTM 1和TP 53 Arg 72 Pro基因型检测。女性CYP 1A 1 Ile 462瓦尔多态性Ile/瓦尔基因型和男性TP 53 Arg 72 Pro多态性Arg/Pro基因型的年龄校正比值比（OR）为2.70（95% CI：1.14-6.40）和4.32（95% CI：1.08-17.2）。CYP 1A 1 T3801 C和GSTM 1多态性的基因型频率无显着差异，观察到控制和情况下，在男性和women.Conclusion：这些结果表明，瓦尔等位基因的CYP 1A I Ile 462 VaI多态性和Pro等位基因的TP 53 Arg 72 Pro polymorphisin有助于GBC的风险增加，日本女性和男性，分别。(c)2007年加拿大临床化学家协会。爱思唯尔公司出版All rights reserved.
Objectives: To examine the relationship between genetic polymorphisms of cytochrome P450 1A1 (CYP1A1), glutathione S-transferase class mu (GSTM1), and tumour protein p53 (TP53) genes, and gallbladder cancer (GBC) risk, a case-control study was conducted.Design and methods: Genotypes of CYP1A1 T3801C, CYP1A1 Ile462VaI, GSTM1, and TP53 Arg72Pro were determined in 54 cases of GBC and 178 controls.Results: The age-adjusted odds ratios (ORs) for the Ile/Val genotype of CYP1A1 Ile462Val polymorphism in women and the Arg/Pro genotype of TP53 Arg72Pro polymorphism in men were observed to be 2.70 (95% CI: 1.14-6.40) and 4.32 (95% Cl: 1.08-17.2), respectively. No significant differences in the genotypic frequencies of CYP1A1 T3801C and GSTM1 polymorphisms were observed between controls and cases in both men and women.Conclusion: These results suggest that the Val allele of CYPIA I Ile462VaI polymorphism and the Pro allele of TP53 Arg72Pro polymorphisin contribute to an increased risk of GBC among Japanese women and men, respectively. (c) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.