Association between maternal Group B Streptococcus surface-protein antibody concentrations and invasive disease in their infants
Association between maternal Group B Streptococcus surface-protein antibody concentrations and invasive disease in their infants
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DOI：
10.1586/14760584.2015.1085307
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发表时间：
2015-12-02
影响因子：
6.2
通讯作者：
Madhi, Shabir A.
中科院分区：
文献类型：
--
作者：
Dangor, Ziyaad;Kwatra, Gaurav;Madhi, Shabir A.
目的：B群链球菌(GBS)表面蛋白是一种具有免疫原性和潜在的候选疫苗。我们的目标是确定选择GBS表面蛋白的母体免疫球蛋白抗体与婴儿侵袭性GBS疾病的相关性。方法：采用配对病例对照研究方法，比较浸润性GBS病儿和正常对照婴儿的GBS免疫原性细菌粘附素、纤维蛋白原结合蛋白A和菌毛岛(PI)抗体水平。结果：随着这些表面蛋白抗体浓度的增加，患病的绝对风险在病例和定居对照组之间没有差异。然而，与纤维蛋白原结合蛋白A相关的侵袭性疾病的风险相对降低，在抗体水平=10,000 AU/ml时，调整后的优势比为0.04(95%CI：0.01-0.69)。结论：我们尚未证明天然产生的纤维蛋白原结合蛋白A、GBS免疫原性细菌粘附素和PI表面蛋白抗体与幼儿侵袭性疾病的风险之间存在关联。这些表面蛋白可能不是合适的GBS疫苗候选疫苗。
Objectives: Group B Streptococcus (GBS) surface-proteins have been shown to be immunogenic and potential vaccine candidates. We aim to determine the association between maternal IgG antibodies to select GBS surface-proteins and invasive GBS disease in their infants. Methods: Using a matched case-control study, maternal antibody levels for GBS-immunogenic bacterial adhesin, fibrinogen-binding protein A and pilus-island (PI) PI-1, PI-2a, PI-2b were compared between infants with invasive GBS disease and well-baby controls. Results: The absolute risk of disease did not differ between cases and colonized controls with increasing antibody concentrations for these surface-proteins. There was, however, a relative risk reduction in invasive disease associated with fibrinogen-binding protein A, with an adjusted odds ratio of 0.04 (95% CI: 0.01-0.69) at antibody levels >= 10,000 AU/ml. Conclusion: We have not demonstrated an association between naturally occurring fibrinogen-binding protein A, GBS-immunogenic bacterial adhesin, and PI surface-protein antibodies and the risk of invasive disease in young infants. These surface-proteins may not be suitable GBS vaccine candidates.