Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction
Angiogenesis markers (VEGF, soluble receptor of VEGF and angiopoietin-1) in very early arthritis and their association with inflammation and joint destruction
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DOI：
10.1016/j.clim.2007.04.014
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发表时间：
2007-08-01
影响因子：
8.6
通讯作者：
Boissier, Marie-Christophe
中科院分区：
文献类型：
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作者：
Clavel, Gaeelle;Bessis, Natacha;Boissier, Marie-Christophe
目的：探讨血管生成标记物在早期关节炎患者中的作用及其与关节进一步破坏的相关性。方法：采用双抗体夹心酶联免疫吸附试验检测310例病情进展<6个月的多发性关节炎患者血清中血管内皮生长因子(VEGF)、血管生成素-1(Ang-1)和可溶性FMS样酪氨酸激酶-1(sFlt-1)的水平。在基线和一年后测量每个血管生成标记物。入选时和入选后1年分别进行手部和足部X线片检查，并采用van der Heidje改良的夏普法进行读数。结果：入选前和入选1年后，血管内皮生长因子水平与炎症的临床和生物学参数相关。SFlt-1水平与生物炎症呈正相关(血沉：r=0.17，p=0.006；C反应蛋白：r=0.14，p=0.02)。血管生成素-1水平与血沉呈正相关(r=0.12，p=0.04)。有趣的是，只有基线时测量的血管内皮生长因子水平与一年后测量的疾病活动评分相关。
Objective: To investigate the involvement of angiogenesis markers in very early arthritis patients and their relevance to predict further joint destruction.Methods: Levels of Vascular Endothelial Growth Factor (VEGF), angiopoietin-1 (Ang-1), and soluble Fms-like tyrosine kinase-1 (sFlt-1) were measured by ELISA in serum samples from 310 patients having polyarthritis, evolving for less than 6 months (VErA cohort). Each angiogenesis marker was measured at baseline and one year later. X-rays of hands and feet were carried out at inclusion and after 1 year and read using the van der Heidje-modified Sharp method.Results: At baseline and after 1 year, VEGF levels were correlated with clinical and biological parameters of inflammation. We also observed a positive correlation between sFlt-1 levels and biological inflammation (Erythrocyte Sedimentation Rate (ESR): r=0.17, p=0.006; C Reactive Protein: r=0.14, p=0.02). Angiopoietin-1 levels were correlated with ESR (r=0.12, p=0.04). Interestingly, only VEGF levels measured at baseline were correlated with Disease Activity Score measured 1 year later.