New, chiral phase transfer catalysts for effecting asymmetric conjugate additions of α-alkyl-α-cyanoacetates to acetylenic esters
New, chiral phase transfer catalysts for effecting asymmetric conjugate additions of α-alkyl-α-cyanoacetates to acetylenic esters
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DOI：
10.1021/ja068119g
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发表时间：
2007-02-07
影响因子：
15
通讯作者：
Maruoka, Keiji
中科院分区：
文献类型：
--
作者：
Wang, Xisheng;Kitamura, Masanori;Maruoka, Keiji
设计了一种新的手性相转移催化剂，用于α-取代-α-氰基乙酸酯与炔酸酯的不对称共轭加成反应，该反应具有高的对映选择性和中等的E/Z选择性。
A new, chiral phase transfer catalyst has been designed for the development of a general and useful procedure on the hitherto unknown, asymmetric conjugate additions of alpha-substituted-alpha-cyanoacetates to acetylenic esters with high enantioselectivity and moderate E/Z selectivity.