SEMI-SYNTHETIC CHASMANTHININE ANALOGUES WITH ANTIFEEDANT EFFECTS AGAINST SPODOPTERA EXIGUA
SEMI-SYNTHETIC CHASMANTHININE ANALOGUES WITH ANTIFEEDANT EFFECTS AGAINST SPODOPTERA EXIGUA
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具有抗甜菜夜蛾拒食作用的半合成春花碱类似物
DOI：
10.3987/com-21-14544
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发表时间：
2021-01-01
期刊：
影响因子：
0.6
通讯作者：
Zhou, Xianli
中科院分区：
文献类型：
--
作者：
Song, Ziyu;Xu, Ke;Zhou, Xianli
活性天然先导化合物的合成和结构修饰是发现新型绿色农药的重要途径。本文制备了天然c19 -二萜生物碱chasmanthinine的19个衍生物，并通过H-1 NMR、C-13 NMR和HR-ESI-MS对其结构进行了明确的鉴定。此外，还研究了标题化合物对夜蛾幼虫的抗取食活性。结果表明，C-14位含噻吩基的化合物p （EC50 = 0.10 mg/cm(2)）的拒食活性最强。本研究首次报道了人工合成的chasmanthinine类似物对甜菜夜蛾（S. exigua）幼虫的拒食作用。
The synthesis and structure modification of active natural lead compounds is an important approach for the discovery of novel green pesticides. Nineteen derivatives of chasmanthinine, a natural C19-diterpenoid alkaloids, were prepared, and their structures were unambiguously determined by H-1 NMR, C-13 NMR, and HR-ESI-MS. Moreover, the antifeedant activities of title compounds were evaluated against larvae of Spodoptera exigua (Hubner). The results illustrated that compound p with a thienyl group at the C-14 position (EC50 = 0.10 mg/cm(2)) showed the strongest antifeedant activities among all tested compounds. This present study is the first report on the antifeedant effects of synthetic chasmanthinine analogs aganist S. exigua (Hubner) larvae.