Impact of BMI on Gonadorelin-Stimulated LH Peak in Premenarcheal Girls with Idiopathic Central Precocious Puberty
Impact of BMI on Gonadorelin-Stimulated LH Peak in Premenarcheal Girls with Idiopathic Central Precocious Puberty
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DOI：
10.1002/oby.21010
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发表时间：
2015-03-01
期刊：
影响因子：
6.9
通讯作者：
Rose, Susan Rogers
中科院分区：
文献类型：
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作者：
Fu, Jun-Fen;Liang, Jian-Feng;Rose, Susan Rogers
目的探讨体质量指数（BMI）对促性腺激素释放激素（GnRH）刺激试验中促黄体生成素（LH）分泌的影响。青春期发育根据坦纳，性激素参数，LH分泌响应GnRH-stimulation.ResultsAround 609女孩体重正常（70.4%），而168名儿童（19.4%）超重，88（10.2%）肥胖。在正常体重组中，GnRH治疗后LH峰值水平显著升高，中位数为9.1 mIU ml（-1）（四分位数5.2-13.1），而超重组和肥胖组LH峰值中位数分别为8.5 mIU ml（-1），四分位数5.3-11.6和6.2 mIU ml（-1），四分位数5.3-11.0。
ObjectiveTo clarify the impact of body mass index (BMI) on luteinizing hormone (LH) secretion in response to gonadorelin (GnRH) stimulation testing in girls diagnosed with idiopathic central precocious puberty (ICPP).MethodsRetrospective single-center cohort study was carried out in 865 confirmed ICPP girls who underwent GnRH stimulation tests. Pubertal development according to Tanner, sex hormone parameters, and LH secretion in response to GnRH-stimulation was compared.ResultsAround 609 girls were of normal weight (70.4%), while 168 children (19.4%) were overweight, and 88 (10.2%) were obese. Peak LH levels after GnRH were much higher in the normal-weight group, with a median of 9.1 mIU ml(-1) (interquartile 5.2-13.1), compared with the median peak LH in the overweight and obese groups (8.5 mIU ml(-1), interquartile 5.3-11.6, and 6.2 mIU ml(-1), interquartile 5.3-11.0, respectively P