Stressing the heart of the matter: re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids.
Stressing the heart of the matter: re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids.
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DOI：
10.3410/m4-13
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Taylor, David A
中科院分区：
文献类型：
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作者：
Anderson, Ethan J;Taylor, David A
尽管n-3多不饱和脂肪酸(PUFAs)对冠心病有明显的治疗效果，但在其他类型的心血管疾病中使用n-3多不饱和脂肪酸(PUFAs)仍然存在争议，并且在将其作为可靠和一致的药物治疗实施方面存在严重障碍。其中最重要的是，在其他形式的心血管疾病中，分子机制和相关剂量尚未牢固确立。在这篇简短的综述中，我们重点介绍了关于n-3多不饱和脂肪酸在心血管系统中作用机制的知识现状。我们还提出了一个新的假设，即来自n-3多不饱和脂肪酸的脂质过氧化产物可能推动了它们对心血管的大部分有益作用，特别是在心肌中。最后，我们讨论了支持这一假说的证据及其可能的临床后果。
Despite their clear therapeutic effects in coronary heart disease, use of n-3 polyunsaturated fatty acids (PUFAs) to treat other types of cardiovascular disease remains controversial, and serious obstacles exist in implementing them as a reliable and consistent drug therapy. The foremost of these is that a molecular mechanism and relevant dosages have not been firmly established in other forms of cardiovascular disease. In this brief review, we highlight the current state of knowledge regarding the mechanisms behind n-3 PUFA action in the cardiovascular system. We also propose the novel hypothesis that lipid peroxidation products derived from n-3 PUFAs may be driving much of their beneficial cardiovascular effects, particularly in the myocardium. We conclude by discussing evidence to support this hypothesis, and its possible clinical ramifications.