The transcriptional regulatory code of eukaryotic cells insights from genome-wide analysis of chromatin organization and transcription factor binding
The transcriptional regulatory code of eukaryotic cells insights from genome-wide analysis of chromatin organization and transcription factor binding
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DOI：
10.1016/j.ceb.2006.04.002
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发表时间：
2006-06-01
影响因子：
7.5
通讯作者：
Ren, Bing
中科院分区：
文献类型：
--
作者：
Barrera, Leah O.;Ren, Bing
真核生物基因表达的控制涉及基因组中转录因子和调控序列之间的组合相互作用。此外，染色质结构和修饰状态在决定转录能力方面起着关键作用。术语“转录调控代码”已被用来描述这些事件的相互作用，在复杂的转录控制。随着在全基因组范围内检测体内蛋白质- dna相互作用方法的成熟，真核细胞全基因组染色质特征和转录因子定位的详细图谱正在丰富我们对这种转录调控代码的性质和本质的理解。快速增长的图谱数量揭示了核小体组成和调控区域染色质重塑的动态性质，并突出了真核细胞中转录调控网络的一些意想不到的特性。
Control of eukaryotic gene expression involves combinatorial interactions between transcription factors and regulatory sequences in the genome. In addition, chromatin structure and modification states play key roles in determining the competence of transcription. The term 'transcriptional regulatory code' has been used to describe the interplay of these events in the complex control of transcription. With the maturation of methods for detecting in vivo protein-DNA interactions on a genome-wide scale, detailed maps of chromatin features and transcription factor localization over entire genomes of eukaryotic cells are enriching our understanding of the properties and nature of this transcriptional regulatory code. The rapidly growing number of maps has revealed the dynamic nature of nucleosome composition and chromatin remodeling at regulatory regions and highlighted some unexpected properties of transcriptional regulatory networks in eukaryotic cells.