Posterior tibial nerve stimulation using a wirelessly powered system in anesthetized cats.
Posterior tibial nerve stimulation using a wirelessly powered system in anesthetized cats.
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使用无线供电系统对麻醉猫进行胫后神经刺激。
DOI：
10.1109/embc.2016.7591717
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Yoo,PaulB
中科院分区：
文献类型：
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作者：
Moazzam,Zainab;Duke,AustinR;Yoo,PaulB
胫后神经刺激（PTNS）是一种有效的膀胱过度活动症（OAB）治疗方法，通常在12周的刺激方案中每周输送一次电脉冲。虽然其作用机制尚不清楚，但PTNS的有效长期给药最近已成为一个令人关注的问题。为此，通过手术将多触点电极放置在麻醉猫的后肢区域中，以（1）研究使用无线供电系统刺激PTN传入神经的可行性和（2）表征刺激频率对调节膀胱活动的植入物驱动效应。使用等容模型，应用频率范围为2-20 Hz的短持续时间超阈值刺激试验。这些结果提供了膀胱功能频率依赖性调节的第一个临床前证据，支持使用一种新的治疗方法，该方法可以在临床上转化为潜在的解决下尿路系统的多种症状。
Posterior Tibial Nerve Stimulation (PTNS) is an effective overactive bladder (OAB) therapy where electrical pulses are typically delivered once per week in a 12-week stimulation regime. While the mechanism of action remains unknown, effective long-term delivery of PTNS has recently become a subject of concern. To this end, a multi-contact electrode was surgically placed in the hind limb region of anesthetized cats to (1) investigate the feasibility of using a wirelessly powered system to stimulate PTN afferents and (2) characterize implant-driven effects of stimulation frequency on modulating bladder activity. Using an isovolumetric model, short-duration, supra-threshold stimulation trials were applied with frequencies ranging from 2-20 Hz. The results provide first pre-clinical evidence of frequency-dependent modulation of bladder function supporting the use of a novel therapeutic approach that can be clinically translated to potentially address multiple symptoms of lower urinary tract system.