Palladium-Catalyzed Asymmetric Dihydroxylation of 1,3-Dienes with Catechols
Palladium-Catalyzed Asymmetric Dihydroxylation of 1,3-Dienes with Catechols
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钯催化 1,3-二烯与儿茶酚的不对称二羟基化
DOI：
10.1002/cjoc.201800540
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发表时间：
2019-03-01
影响因子：
5.4
通讯作者：
Gong, Liu-Zhu
中科院分区：
文献类型：
--
作者：
Fan, Tao;Shen, Hong-Cheng;Gong, Liu-Zhu
研究了手性吡啶双恶唑啉配体催化邻苯二酚与1，3-二烯的不对称双羟基化反应。以易得的原料合成了多种手性2-取代1，4-苯并二氧六环，具有中到高产率和对映选择性。该反应建议通过级联Wacker型羟基钯化/不对称烯丙基化过程进行。
of main observation and conclusion A palladium-catalyzed asymmetric dihydroxylation of 1,3-dienes with catechols is developed using chiral pyridinebis(oxazoline) ligands. Various chiral 2-substituted 1,4-benzodioxanes could be synthesized with moderate to high yields and enantioselectivities from readily available starting materials. The reaction is proposed to proceed through a cascade Wacker-type hydroxypalladation/asymmetric allylation process.