Joint effect of cognitive decline and walking ability on incidence of wandering behavior in older adults with dementia: A cohort study
Joint effect of cognitive decline and walking ability on incidence of wandering behavior in older adults with dementia: A cohort study
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DOI：
10.1002/gps.5714
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发表时间：
2022-05-01
影响因子：
4
通讯作者：
Nishimura, Kunihiro
中科院分区：
文献类型：
--
作者：
Murata, Shunsuke;Takegami, Misa;Nishimura, Kunihiro
目的：游荡行为是痴呆患者最常见的行为障碍之一。据报道，身体功能和流浪行为之间的关联不一致，认知能力下降的影响可能因行走能力而异。本研究的目的是调查高步行能力是否是流浪行为的危险因素，并探讨步行能力和认知功能与老年痴呆症患者的流浪行为的相互作用。方法：这项回顾性队列研究包括3979老年痴呆症。在5年的随访期间，认知功能和行走能力与流浪行为的发生率的关联进行了检查，使用广义线性模型，并计算由于相互作用的相对超额风险（RERI）。此外，认知能力下降和步行能力下降的某些联合效应高于其个体效应之和（RERI [95%置信区间]，重度认知衰退x“在帮助下行走”：1.58 [0.35，2.81];重度认知衰退x“独立”：3.09 [1.05，5.14]）。观察了认知能力下降和行走能力对流浪行为发生率的影响，其影响因其组合而异。
Objectives: Wandering behavior is one of the most troublesome behavioral disturbances in dementia. Inconsistent associations between physical function and wandering behavior were reported, and the effect of cognitive decline may be different according to walking ability. The purposes of this study are to investigate whether high walking ability is a risk factor for wandering behavior and to investigate the interaction of walking ability and cognitive function with wandering behavior in older adults with dementia.Methods: This retrospective cohort study included 3979 elderly adults with dementia. The association of cognitive function and walking ability with incidence of wandering behavior during a 5-year follow-up period were examined using a generalized linear model, and relative excess risk due to interaction (RERI) was calculated.Results: Severe cognitive decline and high walking ability were associated with a higher risk for wandering behavior. Additionally, some joint effects of cognitive decline and walking ability decline were higher than the sum of its individual effects (RERI [95% confidence interval], severe cognitive decline x 'walk with help': 1.58 [0.35, 2.81]; severe cognitive decline x 'independent': 3.09 [1.05, 5.14]).Conclusions: Effects of cognitive decline and walking ability on incidence of wandering behavior were observed, and the effects varied depending on their combination.