Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation
Aryl nitro reduction with iron powder or stannous chloride under ultrasonic irradiation
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DOI：
10.1080/00397910701481195
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Keller, Paul A.
中科院分区：
文献类型：
--
作者：
Gamble, Allan B.;Garner, James;Keller, Paul A.
在35 kHz超声辐射下，芳基硝基化合物在卤素、羰基、腈和酯取代基等敏感官能团存在下的选择性还原，产率为39- 98%。铁粉被证明上级氯化亚锡，具有敏感官能团的高耐受性和在相对短的反应时间内所需的芳基胺的高产率。简单的实验步骤和纯化也使得芳基硝基化合物的铁还原优于其他还原方法。
The selective reduction of aryl nitro compounds in the presence of sensitive functionalities, including halide, carbonyl, nitrile, and ester substituents, under ultrasonic irradiation at 35 kHz is reported in yields of 39-98%. Iron powder proved superior to stannous chloride with high tolerance of sensitive functional groups and high yields of the desired aryl amines in relatively short reaction times. Simple experimental procedure and purification also make the iron reduction of aryl nitro compounds advantageous over other methods of reduction.