Apo lipoprotein A1 gene polymorphisms predict cardio-metabolic risk in South Asian immigrants.
Apo lipoprotein A1 gene polymorphisms predict cardio-metabolic risk in South Asian immigrants.
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Apo脂蛋白A1基因多态性预测南亚移民的心脏代谢风险。
DOI：
10.3233/dma-2012-0856
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Butler MG
中科院分区：
文献类型：
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作者：
Dodani S;Henkhaus R;Dong L;Butler MG
目的：冠状动脉疾病(CAD)是全球主要的死亡原因，在美国，南亚人的负担越来越大。在南亚移民中，影响冠心病的特定基因变异尚未得到充分评估。本研究的目的是确定载脂蛋白A1(APOA1)基因的多态性及其与冠心病危险因素、代谢综合征和高密度脂蛋白(Dys-HDL)失调的关系。方法：对35-65岁无冠心病的南亚人进行了一项基于社区的研究。进行载脂蛋白A1基因测序，并与心血管检查结果进行比较。结果：代谢综合征和高密度脂蛋白紊乱的患病率分别为29.7%和26%。分析了6个新的APOA1基因单核苷酸多肽(SNPs)。6个SNP中有3个(G2、G3和G5)与代谢综合征有关：G2(T655C)(p=0.044)、G3(T756C)(p=0.037)和G5(T1001C)(p=0.037)。载脂蛋白A1基因SNP G1(T319C)与低高密度脂蛋白水平密切相关(p=0.001)。在我们的研究中，APOA1单核苷酸多态与代谢综合征和低高密度脂蛋白的相关性在年龄调整后仍然存在。结论：新基因多态性的发现将有助于进一步了解南亚人群过度冠心病风险的原因，从而制定针对高危人群的预防策略。
Objectives: Coronary artery disease (CAD) is a leading cause of death globally with increasing burden in South Asians in the US. Specific genetic variants that influence CAD have not been fully assessed in South Asian Immigrants. The goal is to identify Apo lipoprotein A1 (APOA1) gene polymorphisms and their association with CAD risk factors, metabolic syndrome and dysfunctional HDL (Dys-HDL). Methods: A community-based study on South Asians aged 35-65 years without CAD was conducted. APOA1 gene sequencing was performed and genotypes compared with cardiovascular findings. Results: The prevalence of metabolic syndrome and dysfunctional-HDL was 29.7% and 26%, respectively. Six novel APOA1 gene single nucleotide peptides (SNPs) were analyzed. Three of the six SNPs (G2, G3, and G5) were found to be associated with metabolic syndrome; G2 (T655C) (p=0.044), G3 (T756C) (p=0.037) and G5 (T1001C) (p=0.037). APOA1 gene SNP G1 (T319C) was highly correlated with low HDL levels (p=0.001). In our study, both associations of APOA1 SNPs with metabolic syndrome and low HDL remained after age-adjustment. Conclusion: Discovery of novel gene polymorphisms will help to understand further the causes of excess CAD risk in South Asians so that preventative strategies targeted to high-risk group can be developed.