Hairy cell leukemia: a clinical review based on 71 cases.
Hairy cell leukemia: a clinical review based on 71 cases.
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毛细胞白血病：基于 71 例的临床评价。
DOI：
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发表时间：
1978
影响因子：
39.2
通讯作者：
D. Golde
中科院分区：
文献类型：
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作者：
H. Golomb;D. Catovsky;D. Golde
我们研究了 71 名毛细胞白血病患者的临床和实验室特征，以确定是否存在对该疾病治疗重要的预后因素。 46%的患者中粒细胞减少低于500/mu 1与严重感染的发生有关，而粒细胞绝对计数高于500/mu 1的患者中这一比例为19%（P小于0.05）。在大多数有血小板减少或白细胞减少症状的患者中，脾切除术可以改善血细胞计数。仅接受脾切除治疗的患者的生存期明显长于仅接受类固醇治疗的患者（P 小于 0.05）。一组年龄稍大、脾肿大程度轻微且外周血中毛细胞很少的患者在没有治疗干预的情况下表现良好。 24 名患者死亡，其中 16 人死于感染过程。该组 4 年精算生存率为 51%，此后没有变化。
We studied the clinical and laboratory characteristics of 71 patients with hairy cell leukemia to ascertain whether prognostic factors important for the therapy of the disease existed. Granulocytopenia of less than 500/mu 1 was associated with the occurrence of a serious infection in 46% of the patients, compared to 19% of patients whose absolute granulocyte count was greater than 500/mu 1 (P less than 0.05). In most patients with symptoms of thrombocytopenia or leukopenia, splenectomy led to improved blood counts. Patients treated with splenectomy only had a significantly longer survival than those treated with steroids only (P less than 0.05). A group of patients who were slightly older and had minimal splenomegaly and few hairy cells in the peripheral blood did well without therapeutic intervention. Twenty-four patients have died, 16 of an infectious process. The actuarial survival for the group is 51% at 4 years, and there has been no change subsequently.