Zinc and cadmium analysis in human prostate neoplasms
Zinc and cadmium analysis in human prostate neoplasms
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DOI：
10.1007/bf02783239
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发表时间：
1997-12-01
影响因子：
3.9
通讯作者：
Krajewska, WM
中科院分区：
文献类型：
--
作者：
Brys, M;Nawrocka, AD;Krajewska, WM
本研究的目的是检验前列腺癌与锌 (Zn) 和镉 (Cd) 浓度变化相关的假设。通过原子吸收光谱法分析正常前列腺、良性前列腺增生 (BPH) 和前列腺癌 (PCA) 中的 Zn 和 Cd。使用石墨炉测量镉含量，通过火焰模式测量锌含量。评估整个组织以及细胞核、质膜和细胞质部分的金属含量。与正常组织相比，观察到 BPH 中 Zn 含量增加，但 PCA 减少。 BPH 和 PCA 中的 Cd 浓度似乎高于正常组织。在同一患者的 BPH 标本中未发现 Zn 和 Cd 水平之间存在相关性。 p 小于或等于 0.05 的概率值被认为表明存在显着差异。获得的结果似乎支持镉致癌性和锌在前列腺癌中的预防作用的假设。对应于溶酶体、线粒体和微粒体亚细胞区室的质膜部分可能对于锌和镉参与人类前列腺肿瘤至关重要。
The objective of this study was to test the hypothesis that prostatic cancer is associated with the changes of zinc (Zn) and cadmium (Cd) concentration. Normal prostate, benign prostatic hyperplasia (BPH), and prostatic carcinoma (PCA) were analyzed for Zn and Cd by atomic absorption spectrometry. Cd level was measured using a graphite furnace and Zn level was measured by flame mode. Metal content was assessed in whole tissues and in nuclear, plasma membrane, and cytosolic fractions. An increase of Zn content in BPH, but a decrease in PCA as compared to normal tissue, was observed. Cd concentration appeared to be higher in BPH and PCA than in normal tissue. No correlation between Zn and Cd level was found in BPH specimens obtained from the same patients. Probability values of p less than or equal to 0.05 were considered to indicate significant differences. Obtained results seem to support the hypothesis of Cd carcinogenicity and preventing function of Zn in prostatic cancer. Plasma membrane fraction corresponding to lysosomal, mitochondrial, and microsomal subcellular compartments are probably critical in Zn and Cd participation in human prostate neoplasms.