Natural course of adolescent major depressive disorder: I. Continuity into young adulthood
Natural course of adolescent major depressive disorder: I. Continuity into young adulthood
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DOI：
10.1097/00004583-199901000-00020
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发表时间：
1999-01-01
影响因子：
13.3
通讯作者：
Seeley, JR
中科院分区：
文献类型：
--
作者：
Lewinsohn, PM;Rohde, P;Seeley, JR
目的：通过比较有青春期抑郁障碍病史的青少年重度抑郁障碍(MDD)患者与有抑郁情绪、非情感障碍和无情绪障碍的青少年适应障碍患者在19岁和24岁之间的心境障碍和非情绪障碍的发生率，来研究青少年重度抑郁障碍(MDD)的病程。方法：对在青春期接受过两次访谈的社区受试者在24岁后完成第三次访谈，评估Axis I精神病理学和反社会及边缘人格障碍：MDD组261人，适应障碍73人，非情感性障碍133人，非情感障碍272人，直至18岁。结果：青春期MDD组明显高于非情感障碍组和无障碍组(MDD年均发病率分别为9.0%，5.6%和3.7%)。患有MDD的青少年在青年期也有很高的非情绪性障碍的发生率(每年的非情感性障碍发生率=6.6%)，但与非情感性障碍的青少年(7.2%)没有区别。心境恶劣和双相情感障碍的患病率很低(
Objective: To examine the course of adolescent major depressive disorder (MDD) by comparing rates of mood and non-mood disorders between age 19 and 24 years in participants with a history of adolescent MDD versus participants with adolescent adjustment disorder with depressed mood, nonaffective disorder, and no disorder. Method: Participants from a large community sample who had been interviewed twice during adolescence completed a third interview assessing Axis I psychopathology and antisocial and borderline personality disorders after their 24th birthday: 261 participants with MDD, 73 with adjustment disorder, 133 with nonaffective disorder, and 272 with no disorder through age 18. Results: MDD in young adulthood was significantly more common in the adolescent MDD group than the nonaffective and no disorder groups (average annual rate of MDD = 9.0%, 5.6%, and 3.7%, respectively). Adolescents with MDD also had a high rate of nonaffective disorders in young adulthood (annual nonaffective disorder rate = 6.6%) but did not differ from adolescents with nonaffective disorder (7.2%). Prevalence rates of dysthymia and bipolar disorder were low (