Significance of arachidonic acid in ocular infections and inflammation.
Significance of arachidonic acid in ocular infections and inflammation.
复制标题
DOI：
10.14800/ics.301
复制
发表时间：
2014-09
影响因子：
--
通讯作者：
T. Tripathi;H. Alizadeh
中科院分区：
文献类型：
--
作者：
T. Tripathi;H. Alizadeh
角膜固有免疫反应主要在调动多种相互关联的角膜脂质途径中发挥重要作用，参与炎症性角膜疾病的发生。由花生四烯酸(AA)衍生的控制细胞增殖、凋亡、新陈代谢和迁移的信号脂质介质被称为二十烷基类化合物、磷脂酰肌醇、鞘磷脂和脂肪酸。越来越多的证据表明，脂质介质在角膜损伤和修复机制中都有重要作用。最近，AA及其代谢产物在病原体感染的角膜中诱导促炎介质和炎性细胞浸润并导致严重角膜炎的作用已被揭示。本文就AA下游信号在角膜炎症性疾病中的新作用，以及AA信号在针对视力威胁疾病的治疗策略中的生物学意义作一综述。
Innate immune responses in the cornea mainly play an important role to mobilize multiple interrelated pathways of corneal lipid, which involve in inflammatory corneal diseases. Signaling lipid mediators derived from arachidonic acid (AA) control cell proliferation, apoptosis, metabolism, and migration, are known as eicosanoids, phosphoinositides, sphingolipids, and fatty acids. Emerging evidences have highlighted the implication of lipid mediators in both injury and repair mechanisms in the cornea. Recently, the role of AA and its metabolites to induce proinflammatory mediators and inflammatory cell infiltration in the pathogen-infected cornea and to cause severe keratitis have been revealed. In this review, we focus on the novel roles of AA downstream signaling in the corneal inflammatory diseases and also the biological relevance of AA signaling in the therapeutic strategies for targeting sight-threatening diseases.