Dynamic association of gammaherpesvirus DNA with core histone during de novo lytic infection of primary cells.
Dynamic association of gammaherpesvirus DNA with core histone during de novo lytic infection of primary cells.
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DOI：
10.1016/j.virol.2011.09.024
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发表时间：
2011-12-20
期刊：
影响因子：
3.7
通讯作者：
Tarakanova VL
中科院分区：
文献类型：
--
作者：
Mounce BC;Tsan FC;Kohler S;Cirillo LA;Tarakanova VL
Association of herpesvirus DNA with histones has important implications for lytic and latent infection; thus herpesviruses arbitrate interactions with histones to productively infect host cells. While regulation of alpha and betaherpesvirus chromatin during lytic infection has been actively investigated, very little is known about interaction of gammaherpesvirus DNA with histones upon de novo lytic infection. Murine gammaherpesvirus-68 (MHV68) is a rodent pathogen that offers a tractable system to study gammaherpesvirus lytic infection in primary cells. In this study we report that MHV68 promoter and orilyt sequences underwent dynamic association with histone H3 during de novo lytic infection of primary macrophages and fibroblasts. Similar to HSV-1, the degree of MHV68 DNA association with histone H3 was dependent on the multiplicity of infection and was further regulated by viral DNA synthesis. Our work sets a precedent for future studies of gammaherpesvirus chromatin during de novo lytic infection.
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