MicroRNAs involved with hepatocellular carcinoma (Review)
MicroRNAs involved with hepatocellular carcinoma (Review)
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MicroRNA 与肝细胞癌相关（综述）
DOI：
10.3892/or.2015.4275
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发表时间：
2015-12-01
期刊：
影响因子：
4.2
通讯作者：
Wang, Ge
中科院分区：
文献类型：
--
作者：
Mao, Bijing;Wang, Ge
肝细胞癌（HCC）是最常见的恶性肿瘤之一，占原发性肝癌的90%。由于高复发率和广泛的转移，HCC通常表现为预后不良。然而，肝癌发生和发展的潜在机制，这显着阻碍了有效的方法，早期发现和治疗的发展仍有待阐明。microRNAs（miRNAs）是一类小分子非编码RNA，与多种疾病尤其是人类恶性肿瘤的发生发展密切相关。许多miRNA在HCC中失调控，这可能为当前的研究提供一些线索。由于miRNAs稳定且易于检测，已报道其在HCC组织、血清/血浆和细胞系中的异位表达。如前所述，miRNA作为肿瘤抑制因子或癌基因，表明miRNA可用作HCC的诊断、治疗和预后标志物。在本综述中，我们评估了关于HCC中失调的miRNAs的最新数据，并回顾了这些miRNAs在HCC诊断和预后中的功能。
Hepatocellular carcinoma (HCC) is one of the most common malignancies, which accounts for 90% of primary liver cancer. HCC usually presents with poor outcomes due to the high rates of tumor recurrence and widespread metastasis. However, the underlying mechanism of HCC initiation and progression, which significantly hindered the development of valid approaches for early detection and treatment remain to be elucidated. As a group of small non-coding RNAs, microRNAs (miRNAs) have been demonstrated to be involved in many types of diseases especially human malignancies. Numerous miRNAs are deregulated in HCC, which may shed some light on current investigations. Since miRNAs are stable and detected easily, their ectopic expression has been reported in HCC tissues, serum/plasma and cell lines. As previously described, miRNAs serve as tumor suppressors or oncogenes, indicating that miRNAs may be useful as diagnostic, therapeutic and prognostic markers of HCC. In the present review, we assessed the latest data regarding dysregulated miRNAs in HCC and reviewed the reported functions of these miRNAs as they apply to the diagnosis and prognosis of HCC.