Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.
Serum TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.
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DOI：
10.1038/s41598-017-05129-y
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发表时间：
2017-07-07
影响因子：
4.6
通讯作者：
Nomura S
中科院分区：
文献类型：
--
作者：
Ishibashi Y;Ohtsu H;Ikemura M;Kikuchi Y;Niwa T;Nishioka K;Uchida Y;Miura H;Aikou S;Gunji T;Matsuhashi N;Ohmoto Y;Sasaki T;Seto Y;Ogawa T;Tada K;Nomura S
Breast cancer remains a common malignancy in women, but the take-up for breast cancer screening programs in Japan is still low, possibly due to its perceived inconvenience. TFF1 and TFF3 are expressed in both breast cancer tissue and normal breast. Serum trefoil proteins were reported as cancer screening markers for gastric, prostate, lung, pancreatic cancer and cholangio carcinoma. The purpose of this study was to examine whether serum trefoil proteins could be screening biomarkers for breast cancer. Serum trefoil proteins in 94 breast cancer patients and 84 health check females were measured by ELISA. Serum TFF1 and TFF3 were significantly higher and serum TFF2 was significantly lower in breast cancer patients. Area under the curve of receiver operating characteristic of TFF1, TFF2, and TFF3 was 0.69, 0.83, and. 0.72, respectively. AUC of the combination of TFF1, TFF2, and TFF3 was 0.96. Immunohistochemically, TFF1 expression was positive in 56.5% and TFF3 was positive in 73.9% of breast cancers, while TFF2 was negative in all tumors. Serum TFF1 had positive correlation with expression of TFF1 in breast cancer tissue. Serum concentrations of TFF1 and TFF3 but not TFF2 are higher in women with breast cancer than in women without breast cancer.
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影响因子：
8
作者：
Buache, E.;Etique, N.;Alpy, F.;Stoll, I.;Muckensturm, M.;Reina-San-Martin, B.;Chenard, M. P.;Tomasetto, C.;Rio, M. C.
通讯作者：
Rio, M. C.
影响因子：
3.3
作者：
Davidson, Ben;Stavnes, Helene Tuft;Wang, Tian-Li
通讯作者：
Wang, Tian-Li
影响因子：
3.7
作者：
Lee CS;Taib NA;Ashrafzadeh A;Fadzli F;Harun F;Rahmat K;Hoong SM;Abdul-Rahman PS;Hashim OH
通讯作者：
Hashim OH
影响因子：
29.4
作者：
Nomura, S;Baxter, T;Goldenring, JR
通讯作者：
Goldenring, JR
影响因子：
2.9
作者：
May, FEB;Church, ST;Westley, BR
通讯作者：
Westley, BR