Acceleration of lipid reproduction by emergence of microscopic motion.
Acceleration of lipid reproduction by emergence of microscopic motion.
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DOI：
10.1038/s41467-021-23022-1
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发表时间：
2021-05-19
影响因子：
16.6
通讯作者：
Katsonis N
中科院分区：
文献类型：
--
作者：
Babu D;Scanes RJH;Plamont R;Ryabchun A;Lancia F;Kudernac T;Fletcher SP;Katsonis N
自然界中有大量的自我繁殖分子，它们支持生命系统的生长和运动。在人工环境中，化学反应也可以表现出复杂的复制动力学，然而将自我复制的分子集成到更大的化学系统中仍然是实现更高阶官能团的挑战。在这里，我们展示了自我繁殖的脂类可以启动、维持和加速辛醇液滴在水中的运动。反过来，辛醇液滴的趋化运动大大增加了脂肪复制的速度。因此，键形成化学和液滴运动之间的相互耦合被建立为分子尺度事件(脂分子的自我繁殖)和微观事件(液滴的趋化运动)之间的相互作用的影响。这种分子化学和微观运动性之间的耦合提供了在微观非均质环境中执行功和催化的替代方法。人工分子系统可以表现出复杂的繁殖动力学，但它们集成到更大的系综中仍然是进化更高阶功能的一个挑战。在这里，作者使用证明，自我繁殖的脂类可以启动和加速辛醇液滴的运动，这些液滴的相互趋化运动大大提高了脂类复制的速度。
Self-reproducing molecules abound in nature where they support growth and motion of living systems. In artificial settings, chemical reactions can also show complex kinetics of reproduction, however integrating self-reproducing molecules into larger chemical systems remains a challenge towards achieving higher order functionality. Here, we show that self-reproducing lipids can initiate, sustain and accelerate the movement of octanol droplets in water. Reciprocally, the chemotactic movement of the octanol droplets increases the rate of lipid reproduction substantially. Reciprocal coupling between bond-forming chemistry and droplet motility is thus established as an effect of the interplay between molecular-scale events (the self-reproduction of lipid molecules) and microscopic events (the chemotactic movement of the droplets). This coupling between molecular chemistry and microscopic motility offers alternative means of performing work and catalysis in micro-heterogeneous environments. Artificial molecular systems can show complex kinetics of reproduction, however their integration into larger ensembles remains a challenge towards evolving higher order functionality. Here authors use show that self-reproducing lipids can initiate and accelerate octanol droplet movement and that reciprocally chemotactic movement of these droplets increases the rate of lipid reproduction substantially.
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