Metabolic interactions with cancer epigenetics.
Metabolic interactions with cancer epigenetics.
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DOI：
10.1016/j.mam.2016.09.001
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发表时间：
2017-04
影响因子：
10.6
通讯作者：
Locasale JW
中科院分区：
文献类型：
--
作者：
Gao X;Reid MA;Kong M;Locasale JW
癌细胞具有已知驱动癌症进展的表观遗传改变。染色质和DNA上的表观遗传翻译后修饰的可逆性使得靶向这些修饰成为癌症治疗的有吸引力的手段。细胞表观遗传状态与细胞代谢相互作用，我们现在开始了解这种相互作用是如何发生的，以及介导其功能的生物学背景。考虑到人们对理解和靶向癌症中的代谢重编程的巨大兴趣，这种联系也为探索癌症的责任提供了机会。这篇综述总结了我们对癌症代谢和表观遗传学相互作用的理解的最新进展。
Cancer cells have epigenetic alterations that are known to drive cancer progression. The reversibility of the epigenetic posttranslational modifications on chromatin and DNA renders targeting these modifications an attractive means for cancer therapy. Cellular epigenetic status interacts with cell metabolism, and we are now beginning to understand the nature of how this interaction occurs and the biological contexts that mediate its function. Given the tremendous interest in understanding and targeting metabolic reprogramming in cancer, this nexus also provides opportunities for exploring the liabilities of cancers. This review summarizes recent developments in our understanding of the interaction of cancer metabolism and epigenetics.