Non-coding RNAs as therapeutic targets in hepatocellular cancer.
Non-coding RNAs as therapeutic targets in hepatocellular cancer.
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DOI：
10.2174/156800912803987904
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发表时间：
2012-11
影响因子：
3
通讯作者：
C. Braconi;T. Patel
中科院分区：
文献类型：
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作者：
C. Braconi;T. Patel
肝细胞癌（HCC）是一种常见的恶性肿瘤，影响全球大量患者，在美国和欧洲的发病率不断增加。目前可用于不可手术HCC患者的治疗方法获益有限。尽管针对选定细胞信号通路的分子靶向疗法已经显示出一些有希望的结果，但它们的影响微乎其微。需要鉴定和探索用于开发新疗法的其他靶点。近年来，一些非蛋白质编码RNA（ncRNA）与肝癌发生和肿瘤进展有关。这些ncRNA基因代表了有希望的癌症靶点。然而，ncRNA基因的治疗靶向尚未用于HCC。使用反义寡核苷酸和病毒载体递送方法已被证明是调节ncRNA表达的可行方法。HCC是评估基于RNA的新型治疗方法的最佳癌症，因为治疗剂有效递送和摄取到肝脏的潜力。在这篇综述中，我们讨论了选择的ncRNA，可以作为潜在的目标，在肝癌治疗和概述的方法来靶向ncRNA的表达。未来的挑战包括需要以可接受的安全性和有效性实现位点特异性靶向。
Hepatocellular carcinoma (HCC) is a common malignancy that affects a large number of patients worldwide, with an increasing incidence in the United States and Europe. The therapies that are currently available for patients with inoperable HCC have limited benefits. Although molecular targeted therapies against selected cell signaling pathways have shown some promising results, their impact has been minimal. There is a need to identify and explore other targets for the development of novel therapeutics. Several non-protein coding RNAs (ncRNA) have recently been implicated in hepatocarcinogenesis and tumor progression. These ncRNA genes represent promising targets for cancer. However, therapeutic targeting of ncRNA genes has not been employed for HCC. The use of antisense oligonucleotides and viral vector delivery approaches have been shown to be feasible approaches to modulate ncRNA expression. HCC is an optimal cancer to evaluate novel RNA based therapeutic approaches because of the potential of effective delivery and uptake of therapeutic agents to the liver. In this review, we discuss selected ncRNA that could function as potential targets in HCC treatment and outline approaches to target ncRNA expression. Future challenges include the need to achieve site-specific targeting with acceptable safety and efficacy.