Implementation of multi-echo-based correlated spectroscopic imaging and pilot findings in human brain and calf muscle.
Implementation of multi-echo-based correlated spectroscopic imaging and pilot findings in human brain and calf muscle.
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DOI：
10.1002/jmri.22624
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发表时间：
2011-08
影响因子：
4.4
通讯作者：
Thomas, M. Albert
中科院分区：
文献类型：
--
作者：
Verma, Gaurav;Lipnick, Scott;Ramadan, Saadallah;Nagarajan, Rajakumar;Thomas, M. Albert
To implement a spatially-encoded Correlated Spectroscopic Imaging (COSI) sequence on 3T MRI/MRS scanners incorporating four echoes to collect four phase-encoded acquisitions per repetition time (TR), and to evaluate the performance and reliability of this four-dimensional (4D) Multi-Echo COSI (ME-COSI) sequence in brain and calf muscle. Typical scan parameters for the 4D datasets were as follows: TR=1500ms, 2000 Hz bandwidth, 8×8 spatial encoding, one average, 64 Δt1 increments and the scan duration was 25 minutes. The performance and test-retest reliability of ME-COSI were evaluated with phantoms and in the occipito-parietal brain tissues and calf of six healthy volunteers (mean age = 32 years old). Regional differences in concentrations of lipids, creatine (Cr), choline (Ch) and carnosine (Car) were observed between spectra from voxels located in tibial marrow, tibialis anterior and soleus muscle. Diagonal and cross peak resonances were identified from several brain metabolites including N-acetyl aspartate (NAA), Ch, Cr, lactate (Lac), aspartate (Asp), glutathione (GSH) and glutamine\glutamate (Glx). Coefficients of variation (CV) in metabolite ratios across repeated measurements were <15% for diagonal and <25% for cross-peaks observed in vivo. The ME-COSI sequence reliably acquired spatially-resolved two-dimensional (2D) Correlated Spectroscopy (COSY) spectra demonstrating the feasibility of differentiating spatial variation of metabolites in different tissues. Multi-echo acquisition shortens scan duration to clinically feasible times.
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影响因子：
3.3
作者：
DUYN, JH;MOONEN, CTW
通讯作者：
MOONEN, CTW
影响因子：
3.3
作者：
KLOSE, U
通讯作者：
KLOSE, U
影响因子：
19.7
作者：
FEINBERG, DA;MILLS, CM;BRANTZAWADZKI, M
通讯作者：
BRANTZAWADZKI, M
DOI：
10.1002/jmri.1880080505
发表时间：
1998-09-01
期刊：
JMRI-JOURNAL OF MAGNETIC RESONANCE IMAGING
影响因子：
--
作者：
Le Roux, P;Gilles, RJ;Carlier, PG
通讯作者：
Carlier, PG
影响因子：
2.5
作者：
MULKERN, RV;WONG, STS;JOLESZ, FA
通讯作者：
JOLESZ, FA