In vivo evidence for post-adolescent brain maturation in frontal and striatal regions
In vivo evidence for post-adolescent brain maturation in frontal and striatal regions
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DOI：
10.1038/13154
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发表时间：
1999-10-01
影响因子：
25
通讯作者：
Toga, AW
中科院分区：
文献类型：
--
作者：
Sowell, ER;Thompson, PM;Toga, AW
我们使用高分辨率结构磁共振图像（MRI）的全脑逐体素统计分析，在空间和时间上绘制了青春期和青年期之间的大脑成熟。在这些年里，大脑成熟的模式与早期发育不同，局限于背侧、内侧和眶额皮质和豆状核的大区域，其他位置的变化相对较小。这种空间和时间模式与大脑发育的死后研究结果一致，并且在这个年龄范围内归因于额叶结构的认知功能的持续发展。
We spatially and temporally mapped brain maturation between adolescence and young adulthood using a whole-brain, voxel-by-voxel statistical analysis of high-resolution structural magnetic resonance images (MRI). The pattern of brain maturation during these years was distinct from earlier development, and was localized to large regions of dorsal, medial and orbital frontal cortex and lenticular nuclei, with relatively little change in any other location. This spatial and temporal pattern agrees with convergent findings from post-mortem studies of brain development and the continued development over this age range of cognitive functions attributed to frontal structures.