Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles
Msps protein is localized to acentrosomal poles to ensure bipolarity of Drosophila meiotic spindles
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DOI：
10.1038/35083025
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发表时间：
2001-07-01
影响因子：
21.3
通讯作者：
Ohkura, H
中科院分区：
文献类型：
--
作者：
Cullen, CF;Ohkura, H
雌性减数分裂纺锤体通常以不依赖中心体的方式形成。本文报道了果蝇减数分裂纺锤体无中心体极蛋白的鉴定。无中心体极至少含有两种与有丝分裂中心体有关的蛋白，即微纺锤体（Msps）和D-TACC。这些蛋白质相互作用，都是维持无中心体纺锤体双极性所必需的。Msps的极性定位依赖于D-TACC和Ncd，驱动蛋白样微管马达。我们认为，由D-TACC和Ncd介导的Msps的极性定位可能对减数分裂纺锤体双极性的稳定至关重要。
The female meiotic spindle is commonly formed in a centrosome-independent manner. Here we report the identification of proteins at acentrosomal poles in the female meiotic spindle of Drosophila, The acentrosomal poles contain at least two proteins, Mini-spindles (Msps) and D-TACC, which are also associated with mitotic centrosomes. These proteins interact with one another and are both required for maintaining the bipolarity of acentrosomal spindles. The polar localization of Msps is dependent on D-TACC and Ncd, a kinesin-like microtubule motor. We propose that the polar localization of Msps mediated by D-TACC and Ncd may be crucial for the stabilization of meiotic spindle bipolarity.